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Cancer has overtaken heart disease and become the leading cause of death worldwide. [ 1 , 2 ] In 2008, approximately 7.6 million people died of cancer, and the cancer rates may further increase by 50% to 15 million new cases in the year 2020 according to the World Cancer Report. Current clinical cancer therapies are limited to surgery, radiotherapy, and(More)
X-ray computed tomography (CT) is regarded as one of most powerful diagnostic imaging techniques. [ 1 ] With deep tissue penetration and high resolution, it is capable of providing 3D images of the entire body with exquisite contrast. Currently, the only CT contrast agents approved for clinical use are small iodinated molecules. [ 2a ] These small iodinated(More)
X-ray computed tomography (CT) is one of the most powerful noninvasive diagnostic imaging techniques in modern medicine. Nevertheless, the iodinated molecules used as CT contrast agents in the clinic have relatively short circulation times in vivo, which significantly restrict the applications of this technique in target-specific imaging and angiography. In(More)
The color change induced by triple hydrogen-bonding recognition between melamine and a cyanuric acid derivative grafted on the surface of gold nanoparticles can be used for reliable detection of melamine. Since such a color change can be readily seen by the naked eye, the method enables on-site and real-time detection of melamine in raw milk and infant(More)
We report here the development of Gd-doped ZnO quantum dots (QDs) as dual modal fluorescence and magnetic resonance imaging nanoprobes. They are fabricated in a simple, versatile and environmentally friendly method, not only decreasing the difficulty and complexity, but also avoiding the increase of particle's size brought about by silica coating procedure(More)
A novel CT contrast agent denoted as BaYbF(5) @SiO(2) @PEG is presented. The as-prepared nanoparticles exhibit significantly enhanced contrast efficacy relative to clinical iodinated agents and maintain higher X-ray attenuation at different voltages, suitable for diagnostic imaging of various patients. Prolonged circulation time in vivo and low toxicity(More)
The widespread forgery in all kinds of paper documents and certificates has become a real threat to society. Traditional fluorescent anti-counterfeiting materials generally exhibit unicolor display and suffer greatly from substitution, thus leading to a poor anti-counterfeiting effect. In this work, unseen but significant enhanced blue down-conversion(More)