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Cancer has overtaken heart disease and become the leading cause of death worldwide. [ 1 , 2 ] In 2008, approximately 7.6 million people died of cancer, and the cancer rates may further increase by 50% to 15 million new cases in the year 2020 according to the World Cancer Report. Current clinical cancer therapies are limited to surgery, radiotherapy, and(More)
We report here the development of Gd-doped ZnO quantum dots (QDs) as dual modal fluorescence and magnetic resonance imaging nanoprobes. They are fabricated in a simple, versatile and environmentally friendly method, not only decreasing the difficulty and complexity, but also avoiding the increase of particle's size brought about by silica coating procedure(More)
X-ray computed tomography (CT) is regarded as one of most powerful diagnostic imaging techniques. [ 1 ] With deep tissue penetration and high resolution, it is capable of providing 3D images of the entire body with exquisite contrast. Currently, the only CT contrast agents approved for clinical use are small iodinated molecules. [ 2a ] These small iodinated(More)
We report a facile and environmentally friendly strategy for high-yield synthesis of highly monodisperse gold nanoparticles with urchin-like shape. A simple protein, gelatin, was first used for the control over shape and orientation of the gold nanoparticles. These nanoparticles, ready to use for biological systems, are promising in the optical(More)
Titanium nitride, an alternative plasmonic material to gold with unique physiochemical properties, has been widely used in microelectronics, biomedical devices and food-contact applications. However, its potential application in the area of biomedicine has not been effectively explored. With the spectral match of their plasmon resonance band and the(More)
X-ray computed tomography (CT) is one of the most powerful noninvasive diagnostic imaging techniques in modern medicine. Nevertheless, the iodinated molecules used as CT contrast agents in the clinic have relatively short circulation times in vivo, which significantly restrict the applications of this technique in target-specific imaging and angiography. In(More)