Kelly Steinmetz

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Colostral cells have been previously shown to mediate antibody-dependent cellular cytotoxicity (ADCC) to herpes to simplex virus-infected cells. A comparison of colostral cells to matched peripheral blood mononuclear cells has revealed significantly lower ADCC activity, higher antibody requirements, and slower kinetics of colostral cell ADCC against(More)
The cellular population of human breast milk collected within 5 days postpartum consists primarily of lipid laden polymorphonuclear leukocytes and macrophages, whereas lymphocytes comprise < 10% of the total cells. A discontinuous density gradient technique was developed to obtain highly enriched (75 +/- 6%) fractions of milk lymphocytes. The majority of(More)
PVP-silica (Percoll) did not inhibit antibody-dependent cellular cytotoxicity in an 18 h 51Cr-release assay. By the use of a simple discontinuous density gradient centrifugation technique, leukocytes from peripheral blood and colostrum were separated into morphologic and cytotoxic functional populations. The major cytotoxic effector cells in colostrum are(More)
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