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  • Stephen A. Gallo, Kelly Sackett, Satinder S. Rawat, Yechiel Shai, Robert Blumenthal
  • Biology, Medicine
  • Journal of molecular biology
  • 2004 (First Publication: 1 May 2004)
  • C-peptides derived from the HIV envelope glycoprotein transmembrane subunit gp41 C-terminal heptad repeat (C-HR) region are potent HIV fusion inhibitors. These peptides interact with the gp41Expand
  • Ofir Korazim, Kelly Sackett, Yechiel Shai
  • Chemistry, Medicine
  • Journal of molecular biology
  • 2006 (First Publication: 1 December 2006)
  • HIV-1 entry into its host cell involves a sequential interaction whereby gp41 is in direct contact with the plasma membrane. Understanding the effect of membrane composition on the fusion mechanismExpand
  • Sophie Shnaper, Kelly Sackett, Stephen A. Gallo, Robert Blumenthal, Yechiel Shai
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2004 (First Publication: 30 April 2004)
  • To infect target cells, HIV-1 employs a virally encoded transmembrane protein (gp41) to fuse its viral envelope with the target cell plasma membrane. We describe the gp41 ectodomain as comprised ofExpand
  • Kelly Sackett, Yechiel Shai
  • Chemistry, Medicine
  • Journal of molecular biology
  • 2005 (First Publication: 1 July 2005)
  • The HIV gp41 protein mediates fusion with target host cells. The region primarily involved in directing fusion, the fusion peptide (FP), is poorly understood at the level of structure and functionExpand
  • Punsisi Upeka Ratnayake, Kelly Sackett, Matthew J Nethercott, David P Weliky
  • Medicine, Chemistry
  • Biochimica et biophysica acta
  • 2015
  • The gp41 protein of the Human Immunodeficiency Virus (HIV) catalyzes fusion between HIV and host cell membranes. The ~180-residue ectodomain of gp41 is outside the virion and is the most importantExpand
  • Kelly Sackett, Matthew J Nethercott, +4 authors David P Weliky
  • Medicine, Chemistry
  • Journal of molecular biology
  • 2010 (First Publication: 19 March 2010)
  • Fusion between viral and host cell membranes is the initial step of human immunodeficiency virus infection and is mediated by the gp41 protein, which is embedded in the viral membrane. TheExpand