Kelly P. Silva

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This study aimed to evaluate differences in plasma and cerebrospinal fluid (CSF) levels of Aβ peptides in older adults with late-life depression compared to non-depressed older controls. We conducted a systematic review and meta-analysis of the literature using PubMed, Web of science and Scopus databases with no search limits for publication dates or(More)
The Hsp90 molecular chaperone is essential for protein homeostasis and in the maturation of proteins involved with cell-cycle control. The low ATPase activity of Hsp90 is critical to drive its functional cycle, which is dependent on the Hsp90 cochaperones. The Activator of Hsp90 ATPase-1 (Aha1) is a protein formed by two domains, N- and C-terminal, that(More)
This paper shows a fuzzy relational clustering method in order to perform the clustering of symbolic data. The presented method yields a fuzzy partition and prototype for each cluster by optimizing an adequacy criterion based on suitable dissimilarity measures. This work considers two volume-based measures that may be applied to data described by(More)
The recording of symbolic data has become a common practice with the advances in database technologies. This paper shows hard and fuzzy relational clustering in order to partition symbolic data. These methods optimize objective functions based on a dissimilarity function. The distance used is a volume based measure and may be applied to data described by(More)
The clustering problem consists in the discovery of interesting groups in a dataset. Such task is very important and widely tackled in the literature. In this paper, we propose an evolutionary method in order to obtain well formed and spatially separated clusters. The proposed algorithm uses a complete solution representation, each partition is represented(More)
One of the main obstacles to obtain an artificial neural network with reasonable performance is the parameter setting. This work proposes a methodology to the automatic definition of RBF (radial basis function) networks with an appropriate configuration for the selected classification problems. We propose the use of a memetic algorithm in order to perform(More)
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