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Psychosocial stress inhibits amplitude of gonadotropin-releasing hormone pulses independent of cortisol action on the type II glucocorticoid receptor.

• Elizabeth R Wagenmaker, Kellie M Breen, Amy E Oakley, Alan J. Tilbrook, Fred J. Karsch
• Endocrinology
• 2009

Our laboratory has developed a paradigm of psychosocial stress (sequential layering of isolation, blindfold, and predator cues) that robustly elevates cortisol secretion and decreases LH pulse… (More)

Does cortisol inhibit pulsatile luteinizing hormone secretion at the hypothalamic or pituitary level?

• Kellie M Breen, Fred J. Karsch
• Endocrinology
• 2004

Elevations in glucocorticoids suppress pulsatile LH secretion in sheep, but the neuroendocrine sites and mechanisms of this disruption remain unclear. Here, we conducted two experiments in… (More)

Does cortisol acting via the type II glucocorticoid receptor mediate suppression of pulsatile luteinizing hormone secretion in response to psychosocial stress?

• Kellie M Breen, Amy E Oakley, Andrew V. Pytiak, Alan J. Tilbrook, Elizabeth R Wagenmaker, Fred J. Karsch
• Endocrinology
• 2007

This study assessed the importance of cortisol in mediating inhibition of pulsatile LH secretion in sheep exposed to a psychosocial stress. First, we developed an acute psychosocial stress model that… (More)

Does season alter responsiveness of the reproductive neuroendocrine axis to the suppressive actions of cortisol in ovariectomized ewes?

• Kellie M Breen, Fred J. Karsch
• Biology of reproduction
• 2006

Season can profoundly influence activity of the hypothalamic-pituitary-adrenal axis and alter reproductive neuroendocrine responsiveness to stress and gonadal steroids. Here we tested the hypothesis… (More)

Cortisol interferes with the estradiol-induced surge of luteinizing hormone in the ewe.

• Elizabeth R Wagenmaker, Kellie M Breen, +4 authors Fred J. Karsch
• Biology of reproduction
• 2009

Two experiments were conducted to test the hypothesis that cortisol interferes with the positive feedback action of estradiol that induces the luteinizing hormone (LH) surge. Ovariectomized sheep… (More)

Does the type II glucocorticoid receptor mediate cortisol-induced suppression in pituitary responsiveness to gonadotropin-releasing hormone?

• Kellie M Breen, Catherine A Stackpole, +5 authors Fred J. Karsch
• Endocrinology
• 2004

Stress-like elevations in plasma cortisol suppress LH pulse amplitude in ovariectomized ewes by inhibiting pituitary responsiveness to GnRH. Here we sought to identify the receptor mediating this… (More)

Role of estradiol in cortisol-induced reduction of luteinizing hormone pulse frequency.

• Amy E Oakley, Kellie M Breen, Alan J. Tilbrook, Elizabeth R Wagenmaker, Fred J. Karsch
• Endocrinology
• 2009

Precise control of pulsatile GnRH and LH release is imperative to ovarian cyclicity but is vulnerable to environmental perturbations, like stress. In sheep, a sustained (29 h) increase in plasma… (More)

New insights regarding glucocorticoids, stress and gonadotropin suppression.

• Kellie M Breen, Fred J. Karsch
• Frontiers in neuroendocrinology
• 2006

This review highlights our recent work investigating the inhibitory effects of acute, physiologic stress-like increases in cortisol on reproductive neuroendocrine activity in sheep, the mechanisms… (More)

Cortisol reduces gonadotropin-releasing hormone pulse frequency in follicular phase ewes: influence of ovarian steroids.

• Amy E Oakley, Kellie M Breen, I. J. Clarke, Fred J. Karsch, Elizabeth R Wagenmaker, Alan J. Tilbrook
• Endocrinology
• 2009

Stress-like elevations in plasma glucocorticoids suppress gonadotropin secretion and can disrupt ovarian cyclicity. In sheep, cortisol acts at the pituitary to reduce responsiveness to GnRH but does… (More)

A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice.

• Alexander S Kauffman, Varykina G. Thackray, +11 authors Pamela L Mellon
• Biology of reproduction
• 2015

Polycystic ovary syndrome (PCOS) pathophysiology is poorly understood, due partly to lack of PCOS animal models fully recapitulating this complex disorder. Recently, a PCOS rat model using letrozole… (More)

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