Kellianne J. Richardson

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ii Acknowledgment My heartfelt thanks to: First and foremost, my advisor Keith L. Shelton, Ph.D., for his good humor, honesty, kindness and feedback. Among other things you built my exposure chambers and sculpted my understanding of this field. I literally could not have completed this project without busting into your office at least two hundred(More)
Nitrous oxide (N2O) gas is a widely used anesthetic adjunct in dentistry and medicine that is also commonly abused. Studies have shown that N2O alters the function of the N-methyl-d-aspartate (NMDA), GABAA, opioid, and serotonin receptors among others. However, the receptors systems underlying the abuse-related central nervous system effects of N2O are(More)
The abuse-related behavioral effects produced by nitrous oxide (N₂O) gas have been suggested as being unique compared with other abused inhalants. The drug discrimination paradigm in animals can be used to study subjective effects of drugs in humans and to test this hypothesis. The goals of the present experiment were to establish N₂O discrimination in mice(More)
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