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We isolated a temperature-sensitive mutant, hrd4-1, deficient in ER-associated degradation (ERAD). The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, our analysis revealed that HRD4/NPL4 is required for a poorly characterized step in ERAD after(More)
Surgical site infection (SSI) after aortic intervention, an uncommon but serious vascular condition, requires patient-specific antibiotic therapy. Effective treatment and prevention requires the vascular surgeon to be cognizant of changing SSI microbiology, advances in antibiotic delivery, and patient characteristics. The majority of aortic graft infections(More)
Vascular surgical site infection (SSI) is caused by pathogenic bacterial strains whose preferred mode of growth is within a surface biofilm. Bacterial biofilm formation can develop within hours to days in a wound and produces a recalcitrant infectious process especially in the presence of a prosthetic graft. The initial steps of biofilm formation are(More)
Arterial duplex testing is used to evaluate patients with lower-limb arterial occlusive or aneurysmal disease to provide clinicians with detailed information on location, extent, and severity of disease. It is possible to detect disease from the visceral aorta to the tibial arteries. Duplex testing is interpreted in conjunction with limb-pressure(More)
PURPOSE To compare the accuracy of inferior vena cava (IVC) filter placement using a bedside technique guided by intravascular ultrasound (IVUS) with a concurrent experience of filter deployment with fluoroscopic venogram imaging. METHODS From November 2006 to December 2009, 195 consecutive IVC filters were placed to prevent pulmonary embolism in 120(More)
OBJECTIVE This study validated duplex ultrasound measurement of brachial artery volume flow (VF) as predictor of dialysis access flow maturation and successful hemodialysis. METHODS Duplex ultrasound was used to image upper extremity dialysis access anatomy and estimate access VF within 1 to 2 weeks of the procedure. Correlation of brachial artery VF with(More)
Duplex ultrasound testing has evolved to be a clinically useful modality for the evaluation of chronic mesenteric ischemia (CMI) due to visceral artery origin atherosclerosis. Patients with known or suspected CMI can be scanned to identify stenosis or occlusion of the celiac, superior mesenteric, and inferior mesenteric arteries. Testing requires expertise(More)
Intraoperative assessment of arterial repairs can be performed using angiography or ultrasound techniques. Duplex ultrasound is an accurate technique to image and assess the hemodynamics of repaired arteries using color and pulsed Doppler velocity spectra recordings. Procedure-specific interpretation criteria should be used to determine the technical(More)
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