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Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients
The present study suggests that fluvoxamine is not less effective in depressive patients carrying the s allele than in the ones carrying the l allele and it is not more effective in Japanese than in Caucasians. Expand
Prediction of Antidepressant Response to Milnacipran by Norepinephrine Transporter Gene Polymorphisms
OBJECTIVE: With a multitude of antidepressants available, predictors of response to different classes of antidepressants are of considerable interest. The purpose of the present study was toExpand
Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder
The present study fails to demonstrate that the genetic polymorphisms of MAOA-VNTR and TPH-A218C affect the antidepressant effect of fluvoxamine in Japanese patients with major depressive disorder. Expand
No association between the serotonergic polymorphisms and incidence of nausea induced by fluvoxamine treatment
Results suggested that three polymorphisms of serotonin (5-HT) neuronal systems did not affect the development of fluvoxamine-induced nausea, and that incidence of nausea was not a phenomenon that predicts the treatment response to fluVoxamine. Expand
The G196A polymorphism of the brain-derived neurotrophic factor gene and the antidepressant effect of milnacipran and fluvoxamine
The results suggest that the BDNF G196A polymorphism in part determines the antidepressant effect of both milnacipran and fluvoxamine. Expand
Influence of the tyrosine hydroxylase val81met polymorphism and catechol‐O‐methyltransferase val158met polymorphism on the antidepressant effect of milnacipran
The purpose of the present study was to determine whether the tyrosine hydroxylase (TH) val81met and catechol‐O‐methyltransferase (COMT) val158met polymorphisms are associated with the antidepressant effect of milnacipran, a serotonin/noradrenaline reuptake inhibitor. Expand
Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms.
The results suggest that NET but not 5-HTT polymorphisms in part determine the antidepressant response to milnacipran. Expand
A three‐factor model of the MADRS in major depressive disorder
It is suggested that the symptoms of MDD, as assessed by the Montgomery‐Asberg Depression Rating Scale, cluster into three factors (dysphoria, retardation, and vegetative symptoms). Expand
The pharmacology of the integrins
The effects of acute treatment with paroxetine, amitriptyline, and placebo on driving performance and cognitive function in healthy Japanese subjects: A double‐blind crossover trial
To assess the effects of antidepressants on driving performance from a different methodological viewpoint in light of the recent traffic accidents.