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In vivo lipid‐derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS

In vivo lipid‐derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide is investigated, using rats treated with intratracheal instillation of LPS as a model for ARDS.
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Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells.

The CpG island in the DR3 gene promoter was specifically methylated to down-modulate the expression of DR-3 protein in rheumatoid synovial cells, which may provide resistance to apoptosis in RA synovIAL cells.
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Simultaneous determination of ten antihistamine drugs in human plasma using pipette tip solid-phase extraction and gas chromatography/mass spectrometry.

The data obtained from determination of diphenhydramine and chlorpheniramine in human plasma after oral administration of the drugs are presented and the regression equations for the ten antihistamines showed excellent linearity.
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Determination of paraquat and diquat in human body fluids by high-performance liquid chromatography/tandem mass spectrometry.

The data obtained from the determination of PQ and DQ in rat blood after oral administration of the compounds are presented, and Selective reaction monitoring (SRM) showed much higher sensitivity for both body fluids.
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Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis.

It is found that experimental colitis was ameliorated in CHOP-null mice, suggesting that CHOP exacerbates the development of colitis.
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Lumbar Instability and Clinical Symptoms: Which Is the More Critical Factor for Symptoms Sagittal Translation or Segment Angulation?

Background: The relationship between radiologic instability and its symptoms is controversial. Previous authors consider flexion–extension radiographs to be of little value in evaluating instability;…
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Therapeutic Effect of Lecithinized Superoxide Dismutase against Colitis

It is suggested that PC-SOD achieves its ameliorative effect against colitis through decreasing the colonic level of ROS and that its ineffectiveness at higher doses is because of the accumulation of hydrogen peroxide.
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[Clinical analysis of the acute exacerbation in patients with idiopathic pulmonary fibrosis].

There is little evidence that currently accepted treatments are effective in Aex of IPF, and further studies are needed to clarify the pathogenesis and contribute to the prevention of Aex.
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A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage to proximal tubular cells via the generation of a radical intermediate.

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Solid-phase microextraction and liquid chromatography/mass spectrometry in drug analysis

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