Keith Roberts

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success of an academic discipline has a lot to do with the attractiveness of its founding ideas and discoveries. These in turn reach the next generation of practitioners through textbooks. Three years after the completion of the Human Genome Project, it is safe to say that molecular cell biology is a success story. The fourth edition of its premiere(More)
BACKGROUND Hepcidin is a 25-residue peptide hormone crucial to iron homeostasis. It is essential to measure the concentration of hepcidin in cells, tissues and body fluids to understand its mechanisms and roles in physiology and pathophysiology. With a mass of 2791 Da hepcidin is readily detectable by mass spectrometry and LC-ESI, MALDI and SELDI have been(More)
The molecular assembly and subsequent nucleation of para-amino benzoic acid (PABA) from ethanolic solutions is probed using a multi-scale and multi-technique approach. This is applied by examining and interrelating information regarding the molecular, solution-state, cluster, solid-state and surface structures to understand why the alpha form of PABA is(More)
In this course, students will attain knowledge about the fundamental processes of how a body develops and maintains itself as a functional organism. Students are introduced to developmental and stem cell biology; tissue inductions and patterning during organogenesis; and the formation of major organs and tissue systems. They will develop an understanding of(More)
This paper describes storm surge simulations made for Sandy (2012) for the Metropolitan New York (NYC) area using the Advanced Circulation (ADCIRC) model forced by the Weather Research and Forecasting (WRF) model. The atmospheric forecast uncertainty was quantified using 11-members from an atmospheric Ensemble Kalman Filter (EnKF) system. A control WRF(More)
Assessing a patient's competence to give informed consent in pre-hospital care is difficult. In the presented case an elderly patient attempted suicide by division of a chronically infected and externalised prosthetic arterial graft. He was able to comprehend his situation and understand the consequences of declining treatment. Without prior knowledge of(More)
This case demonstrates how hyperpigmentation of the nipple due to Paget's disease can imitate malignant melanoma presenting a diagnostic dilemma. A 62-year-old woman was referred by her GP to the West Sussex Breast Unit with a pigmented lesion on her left nipple that had been increasing in size for six months. She had recently moved back to the UK after(More)
Enterobius vermicularis is responsible for a variety of diseases but rarely affects the liver. Accurate characterisation of suspected liver metastases is essential to avoid unnecessary surgery. In the presented case, following a diagnosis of rectal cancer, a solitary liver nodule was diagnosed as a liver metastasis due to typical radiological features and(More)
Treatment of abdominal lymphoma can be associated with bowel stricture or perforation. Rarely, the common bile duct or portal vein can be involved. This is the first case of stricture formation of both the portal vein and common bile duct in a patient following successful treatment of lymphoma. The development of extensive hilar varices rendered surgical(More)