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- Tyler Jay Curiel, George Coukos, +17 authors Weiping Zou
- Nature Medicine
- 2004
Regulatory T (Treg) cells mediate homeostatic peripheral tolerance by suppressing autoreactive T cells. Failure of host antitumor immunity may be caused by exaggerated suppression of tumor-associated… (More)
- Tyler Jay Curiel, Shuang Wei, +19 authors Weiping Zou
- Nature Medicine
- 2003
Suppression of dendritic cell function in cancer patients is thought to contribute to the inhibition of immune responses and disease progression. Molecular mechanisms of this suppression remain… (More)
- Mary Lenora (Nora) Disis, Theodore A Gooley, +5 authors Kathy A Schiffman
- Journal of clinical oncology : official journal…
- 2002
PURPOSE
The HER-2/neu protein is a nonmutated tumor antigen that is overexpressed in a variety of human malignancies, including breast and ovarian cancer. Many tumor antigens, such as MAGE and gp100,… (More)
- Keith L. Knutson, Mary Lenora (Nora) Disis
- Cancer Immunology, Immunotherapy
- 2004
Historically, cancer-directed immune-based therapies have focused on eliciting a cytotoxic T cell (CTL) response, primarily due to the fact that CTL can directly kill tumors. In addition, many… (More)
- Keith L. Knutson, Kathy A Schiffman, Mary Lenora (Nora) Disis
- The Journal of clinical investigation
- 2001
CD4 T-cell help is required during the generation and maintenance of effective antitumor CD8 T cell-mediated immunity. The goal of this study was to determine whether HER-2/neu-specific CD8 T-cell… (More)
- Kimberly R. Kalli, Ann L. Oberg, +4 authors Lynn C. Hartmann
- Gynecologic oncology
- 2008
OBJECTIVES
Folate receptor alpha (FRalpha) is a folate-binding protein overexpressed on ovarian and several other epithelial malignancies that can be used as a target for imaging and therapeutic… (More)
- Marta Santisteban, Jennifer M Reiman, +10 authors Keith L. Knutson
- Cancer research
- 2009
The breast cancer stem cell (BCSC) hypotheses suggest that breast cancer is derived from a single tumor-initiating cell with stem-like properties, but the source of these cells is unclear. We… (More)
- James W. Krempski, Lavakumar Karyampudi, +6 authors Keith L. Knutson
- Journal of immunology
- 2011
Within the ovarian cancer microenvironment, there are several mechanisms that suppress the actions of antitumor immune effectors. Delineating the complex immune microenvironment is an important goal… (More)
Despite significant progress in the treatment of breast cancer, particularly through the use of targeted therapy, relapse and chemoresistance remain a major hindrance to the fight to minimize the… (More)
The specificity and potency of the immune system make immunotherapy a potential strategy for the treatment of cancer. To exploit this potential, we have developed cell-based cancer vaccines… (More)