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Gene expression profiling of serrated polyps identifies annexin A10 as a marker of a sessile serrated adenoma/polyp
It is shown that SSA/Ps and MVHPs have significant overlap in gene expression, but also important differences, particularly in cancer‐related pathways.
Gastric Proteins MUC5AC and TFF1 as Potential Diagnostic Markers of Colonic Sessile Serrated Adenomas/Polyps
- M. Khaidakov, Keith K. Lai, +5 authors C. Hagedorn
- Biology, MedicineAmerican journal of clinical pathology
- 18 October 2016
The results suggest that the analysis of expression of MUC5AC and TFF1 may be useful for differentiating SSA/Ps from HPs and that crypt morphology may be at least partly due to overproduction of highly viscous gastric mucins and that these proteins may play a role in the serrated pathway to colon carcinogenesis.
Microanatomy of the cervical and anorectal squamocolumnar junctions: a proposed model for anatomical differences in HPV-related cancer risk
The anal transition zone does not harbor a single monolayer of residual undifferentiated embryonic cells and the dominant tumor immunophenotype is in keeping with an origin in metaplastic squamous rather than squamocolumnar junction (CK7-positive) epithelium, revealing two fundamental differences between the anus and the cervix.
Risk for Colorectal Neoplasia in Patients with Inflammatory Bowel Disease and Mucosa Indefinite for Dysplasia
Patients with IBD and IND are at significant risk for colorectal dysplasia and cancer and should be closely followed.
Fatal parasitic meningoencephalomyelitis caused by Halicephalobus deletrix : a case report and review of the literature.
- S. Ondrejka, G. Procop, Keith K. Lai, R. Prayson
- Biology, MedicineArchives of pathology & laboratory medicine
- 1 April 2010
Although extremely rare, the Halicephalobus deletrix organism needs to be considered in the differential diagnosis of human helminthic infection of the central nervous system.
Cystoisospora belli Infection of the Gallbladder in Immunocompetent Patients: A Clinicopathologic Review of 18 Cases
- Keith K. Lai, Hannah E. Goyne, +5 authors Deepa T. Patil
- MedicineThe American journal of surgical pathology
- 1 August 2016
On the basis of the clinical follow-up, gallbladder cystoisosporiasis in immunocompetent individuals appears to be a self-limited infection.
Fungal Infections of the Gastrointestinal Tract in the Immunocompromised Host: An Update
This review will focus on several important emerging fungal infections in immunocompromised patients, including Candida and Aspergillus species, which are emerging as increasingly common pathogens.
Enterocolitis in immunocompromised patients.
This review focuses on common causes of enterocolitis in the immunocompromised with attention to primary immunodeficiency disorders, the post-transplant setting, chemotherapy-related injury, and a select group of common or emerging infections.
Alcohol Consumption Promotes Diethylnitrosamine-Induced Hepatocarcinogenesis in Male Mice through Activation of the Wnt/β-Catenin Signaling Pathway
- K. Mercer, L. Hennings, +5 authors M. Ronis
- Biology, MedicineCancer Prevention Research
- 28 April 2014
It is suggested that chronic EtOH consumption activates the Wnt/β-catenin signaling pathways to increase hepatocyte proliferation, thus promoting tumorigenesis following an initiating insult to the liver.
Overexpression of p53 predicts colorectal neoplasia risk in patients with inflammatory bowel disease and mucosa changes indefinite for dysplasia
- B. Horváth, Ganglei Liu, Xian-rui Wu, Keith K. Lai, B. Shen, Xiuli Liu
- MedicineGastroenterology report
- 10 June 2015
Overexpression of p53 and age are associated with neoplastic progression and the predictive value of the two markers for neoplasia risk in the IBD-IND population is determined.