Keith J. Kelleher

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Patterned networks of hippocampal neurons were generated on peptide-coated gold substrates prepared by microscope projection photolithography and microcontact printing. A 19 amino acid peptide fragment of laminin A (PA22-2) that includes the IKVAV cell adhesion domain was used to direct patterns of cell adhesion in primary culture. Microscale grid patterns(More)
Voltage propagation through neurons is a complicated process dependent on the concentrations and kinetics of ion channels, as well as the morphology of the dendrites. The task of recording the level of activation within different parts of the neuron is challenging, given the small size of the constituent structures, and the fast timescale of the signals.(More)
Changes in neural connectivity are thought to underlie the most permanent forms of memory in the brain. We consider two models, derived from the clusteron (Mel, Adv Neural Inf Process Syst 4:35-42, 1992), to study this method of learning. The models show a direct relationship between the speed of memory acquisition and the probability of forming appropriate(More)
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