Keith Houck

Learn More
OBJECTIVE Thousands of chemicals are in common use, but only a portion of them have undergone significant toxicologic evaluation, leading to the need to prioritize the remainder for targeted testing. To address this issue, the U.S. Environmental Protection Agency (EPA) and other organizations are developing chemical screening and prioritization programs. As(More)
Information seeking is an important but often difficult task, especially when it involves large and complex data sets. We hypothesize that a context-sensitive interaction paradigm would greatly assist users in their information seeking. Such a paradigm would allow users to both express their requests and receive requested information in context. Driven by(More)
In a multimodal human-machine conversation, user inputs are often abbreviated or imprecise. Sometimes, only fusing multimodal inputs together cannot derive a complete understanding. To address these inadequacies, we are building a semantics-based multimodal interpretationframework called MIND (Multimodal Interpretation for Natural Dialog). The unique(More)
Multimodal conversation systems allow users to interact with computers effectively using multiple modalities, such as natural language and gesture. However, these systems have not been widely used in practical applications mainly due to their limited input understanding capability. As a result, conversation systems often fail to understand user requests and(More)
BACKGROUND Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that control a range of cellular processes. Persistent stimulation of some NR is a non-genotoxic mechanism of rodent liver cancer with unclear relevance to humans. Here we report on a systematic analysis of new in vitro human NR activity data on 309 environmental(More)
The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids, and glucose. Because endogenous chemicals bind and activate FXR, it is important to examine which xenobiotic compounds would disrupt normal receptor function. We used a cell-based human FXR β-lactamase (Bla) reporter gene assay to profile the Tox21 10K compound collection of(More)
One of the rate-limiting procedures in a developmental zebrafish screen is the morphological assessment of each larva. Most researchers opt for a time-consuming, structured visual assessment by trained human observer(s). The present studies were designed to develop a more objective, accurate and rapid method for screening zebrafish for dysmorphology.(More)
To adapt the use of GH3.TRE-Luc reporter gene cell line for a quantitative high-throughput screening (qHTS) platform, we miniaturized the reporter gene assay to a 1536-well plate format. 1280 chemicals from the Library of Pharmacologically Active Compounds (LOPAC) and the National Toxicology Program (NTP) 1408 compound collection were analyzed to identify(More)