Keith Brown

Learn More
Despite their therapeutic potential, progress in generating fully differentiated forebrain neurons from embryonic stem cells (ESCs) has lagged behind that from more caudal regions of the neuraxis. GABAergic interneuron precursors have the remarkable ability to migrate extensively and survive after transplantation into postnatal cortex, making them an(More)
p52 is a subunit of nuclear factor (NF)-kappa B transcription factors, most closely related to p50. Previously, we have shown that p52, but not p50 homodimers can form transactivating complexes when associated with Bcl-3, an unusual member of the I kappa B family. To determine nonredundant physiologic roles of p52, we generated mice deficient in p52. Null(More)
The fractional Fourier transform (FrFT) provides a valuable tool for the analysis of linear chirp signals. This paper develops two short-time FrFT variants which are suited to the analysis of multicomponent and nonlinear chirp signals. Outputs have similar properties to the short-time Fourier transform (STFT) but show improved time-frequency resolution. The(More)
In Fall 2013 we offered an open online Introduction to Recommender Systems through Coursera, while simultaneously offering a for-credit version of the course on-campus using the Coursera platform and a flipped classroom instruction model. As the goal of offering this course was to experiment with this type of instruction, we performed extensive evaluation(More)
Glutamate is the primary excitatory neurotransmitter in the brain, and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type glutamate receptors mediate most fast synaptic transmission. AMPA receptors are tetrameric assemblies composed from four possible subunits (GluR1-4). In hippocampal pyramidal cells, AMPA receptors are heteromeric(More)
1.0 ABSTRACT, This paper describes a computational pragmatic model which is geared towards providing helpful answers to modal and hypothetical questions. The work brings together elements from fonnal. semantic theories on modality m~d question answering, defines a wkler, pragmatically flavoured, notion of answerhood based on non-monotonic inference aod(More)
To date most sonars use narrow band pulses and often only the echo envelope is used for object detection and classification. This paper considers the advantages afforded by bio-inspired sonar for object identification and classification through the analysis and the understanding of the broadband echo structure. Using the biomimetic dolphin based sonar(More)
BACKGROUND The functional split model of consultant psychiatrist care for inpatients has been one of the major service redesign that has occurred in the NHS in the last decade. It is unclear if this new split model offers any advantages over the previous sectorised model of working. More recent evidence has suggested that patients, carers and professionals(More)
This paper uses advanced time-frequency signal analysis techniques to generate new models for bio-inspired sonar signals. The inspiration comes from the analysis of bottlenose dolphin clicks. These pulses are very short duration, between 50 and 80 micros, but for certain examples we can delineate a double down-chirp structure using fractional Fourier(More)
  • Paula M Pickering, Patrice Mcmahon, Valery Perry, Zsuzsa Csergo, David Chandler, Florian Bieber +7 others
  • 2013
This investigation explores the conditions under which the EU state-building model is most likely to help produce substantive democratic political reform in the Western Balkans. Data gathered in 2008 and 2009 in Croatia, Bosnia-Herzegovina, and Macedonia suggest that the priority, clarity, and full conditionality of EU rules, together with weak domestic(More)