Keith A. Butler

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Cigarette smoke-triggered inflammation is considered to play a central role in the development of chronic obstructive pulmonary disease by a mechanism that may involve enhanced proinflammatory gene transcription. Histone acetylation and deacetylation is a key regulator of the specificity and duration of gene transcription. Disruption in the nuclear histone(More)
OD0ruWDDD ~WgJ0W@@C?0WgJ IVJ ~ ~ 1 0 Usability has become a competi-u U U eJ rive necessity for the commercial success of sofrware. It is also a requirement for internal sofrware systems intended to improve a About the Author KEITH A. BUTLER is a senior principal scientist at Boeing in the Software Technology Program, and one of the originators of usability(More)
Carroll and Campbell [2] and Suchman [11] have also argued that software embodies user work processes, but stopped short of examining the profound implications for organizations and businesses. They need to respond to accelerating change in the world by improving their work processes continuously , and in some cases by reengineering them completely. Often(More)
We present the case study of a complex, mixed-initiative scheduling system to illustrate <i>Work-Centered Design</i> (WCD), a new approach for the design of information systems. WCD is based on theory of distributed cognition and extends established user-centered methods with abstract task modeling, using innovative techniques for work ontology and(More)
We describe our work on a User-Centered Development Environment (UCDE). UCDE is based on emerging, object-oriented software technologies, and its purpose is to investigate how software development can function as an extension of business process improvements. We focus on a method to develop business-oriented components (BOCs). BOCs are software objects that(More)
Our objective was to demonstrate how software methods for information systems can function as an integral part of advanced methods for re-engineering and continuously improving business processes. We report the feasibility of version 0.3 of the tools for a User-Centered Development Environment with Distributed Application Services. Our approach was to(More)