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—Complex services may be dynamically composed through combining distributed components on demand (i.e., when requested by a user) in order to provide new services without preinstallation. Several systems have been proposed to dynamically compose services. However, they require users to request services in a manner that is not intuitive to the users. In(More)
This paper presents a semantics-based dynamic service composition architecture that composes an application through combining distributed components based on the semantics of the components. This architecture consists of a component model called Component Service Model with Semantics (CoSMoS), a middleware called Component Runtime Environment (CoRE), and a(More)
Dynamic service composition provides the potential for future applications to adapt to various user preferences and contexts. Despite its difficulties, dynamic service composition provides several benefits, namely, flexibility, adaptability, and availability. However, existing dynamic service composition systems lack extensibility and understandability.(More)
The corneal endothelium maintains corneal transparency; consequently, its dysfunction causes severe vision loss. Tissue engineering-based therapy, as an alternative to conventional donor corneal transplantation, is anticipated to provide a less invasive and more effective therapeutic modality. We conducted a preclinical study for cell-based therapy in a(More)
Purpose Rho kinase (ROCK) pathways control fundamental cell functions, making ROCK an important therapeutic target in several pathophysiologic conditions. The purpose of this study was to investigate whether inhibition of ROCK can suppress apoptosis of the corneal endothelium and to determine the role of ROCK signaling in regulating apoptosis. Methods The(More)
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