Keisuke Takahashi

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1alpha,25-Dihydroxy-2beta-(3-hydroxypropoxy)vitamin D(3) (ED-71), an analog of active vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] is under phase III clinical trials in Japan for the treatment of osteoporosis and bone fracture prevention. Since ED-71 has a substituent at the 2beta-position of the A-ring, it is recognized that the(More)
Dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis is one of the most prominent neurobiological findings in major depressive disorder (MDD). The relationship of regional brain metabolism to HPA axis dysfunction in depressed patients, however, is still unclear. In this study, to examine the clinical pharmacotherapeutic effects on HPA axis(More)
STUDY DESIGN Positional magnetic resonance imaging (MRI) study of control subjects. OBJECTIVES To determine dimensional changes in the lumbar dural sac as a function of posture, and to establish changes between the supine, erect and seated positions. SUMMARY OF BACKGROUND DATA Studies using computerized tomography and MRI were done to determine the(More)
STUDY DESIGN The length of the cervical cord in healthy volunteers was measured in the supine and erect position using positional magnetic resonance imaging (MRI). OBJECTIVE To assess the relationship between the length of the cervical cord and cervical posture in healthy volunteers. SUMMARY OF BACKGROUND DATA A number of detailed descriptions of the(More)
1alpha,25-Dihydroxy-2beta-(3-hydroxypropoxy)vitamin D(3) (ED-71), an analog of active vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], possesses a hydroxypropoxy substituent at the 2beta-position of 1,25(OH)(2)D(3). ED-71 has potent biological effects on bone and is currently under phase III clinical studies for bone fracture prevention. It(More)
MytiLec; a novel lectin isolated from the Mediterranean mussel (Mytilus galloprovincialis); shows strong binding affinity to globotriose (Gb3: Galα1-4Galβ1-4Glc). MytiLec revealed β-trefoil folding as also found in the ricin B-subunit type (R-type) lectin family, although the amino acid sequences were quite different. Classification of R-type lectin family(More)
Serotonin (5-hydroxytriptamin, 5-HT) triggers germinal vesicle breakdown (GVBD) of oocytes and the transporting of the mature oocyte through the gonoduct via cilia motility in bivalves. The 5-HT receptor in the oocyte membrane of the Japanese scallop, Patinopecten yessoensis, has been pharmacologically characterized as a mixed profile of 5-HT(1)/5-HT(2) and(More)
— This paper presents part of an ongoing project to design a wearable supportive device, in particular for the facial paralyzed patients to enhance facial expressiveness. As various complications can result in facial disfigurement and loss of functionality in facial muscles it is required to develop a supporting device for people with such conditions. The(More)