Total Synthesis of (+)--Erythroidine
- Hironori Fukumoto, Keisuke Takahashi, J. Ishihara, S. Hatakeyama
- Chemistry
- 21 April 2006
Synthesis and preliminary biological evaluation of 20-epi-eldecalcitol [20-epi-1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3: 20-epi-ED-71]
- S. Hatakeyama, M. Yoshino, N. Kubodera
- Biology, MedicineJournal of Steroid Biochemistry and Molecular…
- 1 July 2010
Synthesis and biological evaluation of a 3-positon epimer of 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71).
- S. Hatakeyama, S. Nagashima, N. Kubodera
- Medicine, BiologyJournal of Steroid Biochemistry and Molecular…
- 2007
Synthesis of 3-epi-ED-71 and investigations of in vitro suppression of PTH using bovine parathyroid cells are described and ED-71 showed weak activity towards PTH suppression in the authors' assays.
β-Isocupreidine—Hexafluoroisopropyl Acrylate Method for Asymmetric Baylis—Hillman Reactions.
- Ayako Nakano, Sakie Kawahara, S. Hatakeyama
- Chemistry
- 23 May 2006
β-Isocupreidine–hexafluoroisopropyl acrylate method for asymmetric Baylis–Hillman reactions
- Ayako Nakano, Sakie Kawahara, S. Hatakeyama
- Chemistry
- 9 January 2006
Pd(II)-catalyzed ligand controlled synthesis of pyrazole-4-carboxylates and benzo[b]thiophene-3-carboxylates.
- Y. Dhage, Hiroki Daimon, Keisuke Kato
- ChemistryOrganic and biomolecular chemistry
- 15 October 2014
A simple change of the ligand (solvent) allowed controlled, effective switching between cyclization-carbonylation-cyclization-coupling (CCC- coupling) reactions and cyclized- carbonylation reactions.
Total synthesis of oxazolomycin A.
- Kohei Eto, M. Yoshino, Keisuke Takahashi, J. Ishihara, S. Hatakeyama
- ChemistryOrganic Letters
- 2 September 2011
The first total synthesis of oxazolomycin A, a structurally novel oxazole polyene γ-lactam/β-lactone antibiotic, is described. Key features include the stereocontrolled construction of the right-hand…
Total synthesis of (-)-kaitocephalin based on a Rh-catalyzed C-H amination.
- Keisuke Takahashi, D. Yamaguchi, J. Ishihara, S. Hatakeyama
- Chemistry, BiologyOrganic Letters
- 5 March 2012
A total synthesis of (-)-kaitocephalin, an ionotropic glutamate receptor antagonist, is accomplished in highly stereocontrolled manner via Overman rearrangement, rhodium-catalyzed benzylic C-H…
pentalenes by a rhodium-catalysed stitching reaction †
- Keisuke Takahashi, S. Ito, R. Shintani, K. Nozaki
- Chemistry
- 2016
A rhodium-catalysed stitching reaction between 2-(silylethynyl)arylboronates and 2-(silylethynyl)aryl bromides has been developed for the synthesis of unsymmetric dibenzo[a,e]pentalenes. The…
Formal [4 + 1]-cycloaddition of homopropargyl alcohols to diazo dicarbonyl compounds giving substituted tetrahydrofurans.
- Fumiya Urabe, Shohei Miyamoto, Keisuke Takahashi, J. Ishihara, S. Hatakeyama
- ChemistryOrganic Letters
- 13 January 2014
A novel formal [4 + 1]-cycloaddition of readily available homopropargyl alcohols with diazo dicarbonyl compounds is described, which involves tandem O-H insertion/Conia-ene cyclization under…
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