Keisuke Nakayama

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BACKGROUND Chronic Kidney Disease (CKD) has been shown to be a risk factor for mortality as well as for morbidity such as cardiovascular disease (CVD) in the general population. However, in the context of CVD events, there is a difference in the incidence of cardiac and stroke events between Western and Asian populations. Although a high prevalence of(More)
BACKGROUND Accelerated burst of polymorphonuclear leukocytes (PMNs) may be involved in the primary pathology of enhanced oxidative stress in patients with chronic kidney disease (CKD); however, the precise mechanism remains unknown. Methylglyoxal (MGO), an alpha-oxoaldehyde reportedly elevated in CKD, could induce apoptosis in several cell lines, and(More)
BACKGROUND Hydrogen (H(2)) reportedly produces an antioxidative effect by quenching cytotoxic oxygen radicals. We studied the biological effects of water with dissolved H(2) on ischemia-induced cardio-renal injury in a rat model of chronic kidney disease (CKD). METHODS Dahl salt-sensitive rats (7 weeks old) were allowed ad libitum drinking of filtered(More)
The present study aimed to clarify the beneficial effect of allopurinol on cardiovascular morbidity and mortality in a cohort of hypertensive nephropathy patients with impaired kidney function. One hundred and seventy-eight patients diagnosed with hypertensive nephropathy and presenting with impaired kidney function (estimated glomerular filtration rate <45(More)
Human serum albumin is composed of human mercaptoalbumin (HMA) with cysteine residues having reducing powers and oxidized human non-mercaptoalbumin. The aim of this study is to clarify whether such redox state of albumin (HSA-redox) influences the incidence of cardiovascular disease (CVD) in chronic kidney disease patients on regular hemodialysis (HD). We(More)
The competence to consent to treatment of 26 adults with stage 5 predialysis chronic kidney disease (CKD) (16 males, 10 females, age; 58 +/- 11 years, creatinine clearance; 10.1 +/- 3.9 mL/min)was assessed using two kinds of format: the MacArthur Competence Assessment Tool-Treatment (MacCAT-T) and mini-mental-state examination (MMSE). The MacCAT-T revealed(More)
BACKGROUND alpha-Oxoaldehydes such as glyoxal (GO), methylglyoxal (MG), and 3-deoxyglucosone (3DG) are precursors of advanced glycation end products and exert direct toxicity to cells and tissues. Plasma levels of these substances are reportedly elevated in diabetes and dialysis patients, but the data on exact levels and clinical significance in chronic(More)
One major precursor of carbonyl stress, methylglyoxal (MG), is elevated in the plasma of chronic kidney disease (CKD) patients, and this precursor contributes to the progression of vascular injury, hypertension and renal injury in diabetic nephropathy patients. This molecule induces salt-sensitive hypertension via a reactive oxygen species-mediated pathway.(More)
Taurine at 10 mM had no effect on basal binding of [3H]diazepam to the membranes, while it significantly inhibited a GABA-stimulated binding of [3H]diazepam in cerebral cortex, hippocampus, but not in cerebellum. The inhibition by taurine in the presence of GABA (1μM to 1 mM) was not competitive. At low concentrations (0.04 to 0.2 nM) the binding of(More)