Keisuke Hanada

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PURPOSE To test whether diffusion tensor imaging could evaluate potential motor capability of patients with chronic cerebral infarction. METHODS We used constraint-induced movement therapy (CIMT) as a rehabilitation, which reveals potential motor capability. We also investigated the relationship between the outcome of CIMT and the ratio between fractional(More)
We investigated longitudinally the circadian body temperature rhythms in 65 inpatients with various mental disorders, 38 of whom had major depressive episodes, by estimating the deep body temperature from the skin surface every 2 h for a consecutive 48-h period. To estimate the circadian rhythm, the data obtained were analyzed by the least-squares method(More)
To study the possibility and potency of periodic maternal deprivation (PMD) in entraining the circadian rhythm of rat pups, access to the natural mother of which pups were optically enucleated on the day of birth (day 1) was restricted to either light phase (L-group) or dark phase (D-group) for various durations beginning on various days during the nursing(More)
In order to perform the dexamethasone suppression test (DST) with saliva as an alternative to serum, we assayed directly the cortisol concentrations in 25 microliters saliva samples, using a commercial radioimmunoassay kit for serum cortisol with minor modifications. Cortisol in saliva showed a diurnal rhythm parallel to that of cortisol in serum samples(More)
Adrenocortical stimulation with ACTH both in the morning (M-test) and in the evening (E-test) and the dexamethasone suppression test were carried out in patients suffering from endogenous depression (DEP) and normal controls (NOR). A greater cortisol release in DEP was recognized than in NOR in the M-test, an earlier peak response of DEP was shown in the(More)
For further investigation of the role of rat dams in setting the phase of pups' endogenous circadian rhythm, periodic maternal deprivation experiments were performed. Access of intact original mothers to blinded pups was restricted to light phase (L-Suckling pups) or dark phase (D-suckling pups) under 12-12 h light-dark alternation throughout the nursing(More)
BACKGROUND/AIMS Existing cognitive measures for moderate-to-severe dementia have shown floor effects and an inability to assess the remaining cognitive function, especially for profound dementia. METHODS We constructed the Cognitive Test for Severe Dementia (CTSD), which consists of 13 items covering 7 cognitive domains, and examined its reliability and(More)
We designed hexakis(phenylethynyl)benzene derivatives with a tertiary amide group on each blade to achieve a helically biased propeller arrangement through the complexation-induced intramolecular transmission of point chirality. A hydrogen-bonding ditopic guest was captured at two amide groups, and thus could pair two neighboring blades to form a(More)