Keishi Komoriyama

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Adult male and female spontaneously hypertensive rats (SHR-Okamoto, Kyoto) were gonadectomized when they were 17 weeks old. Intact SHR showed a progressive increase of their blood pressure with growth, attaining systolic pressure levels of 194-208 in males and 163-173 mmHg in females when they were 29-30 weeks old. During this same period, the(More)
Adrenergic regulation of adenylate cyclase activities in the zona glomerulosa (the capsular fraction) and the zona fasciculata-reticularis (the decapsulated fraction) from rat adrenocortical glands has been investigated. Specific binding of [3H]dihydroalprenolol to the membrane from the capsular and the decapsulated fractions was saturable with dissociation(More)
Exposure of rat prostatic tissues to isoproterenol resulted in rapid desensitization of their catecholamine-sensitive adenylate cyclase which was associated with reduction of available beta-adrenoceptors and a loss of guanine nucleotide-mediated regulation of agonist binding to these receptors. The effect of isoproterenol treatment on responsiveness of the(More)
Acetylcholine significantly inhibited isoproterenol-stimulated adenosine 3',5'-monophosphate (cAMP) levels of rat prostatic tissue in a concentration-dependent fashion. Atropine but no hexamethonium reversed the inhibitory action of acetylcholine. Tetracaine and verapamil abolished the inhibitory effect of acetylcholine on isoproterenol-stimulated(More)
We evaluated the dynamics of endogeneous steroid hormones in hypercholesterolemic rats (HLR) F14, F10 in part, obtained by brother-sister mating of Sprague Dawley strain animals. Plasma free and total cholesterol levels in F14 and F10 were significantly high both in both sexes as compared with controls, however, hypertension did not always occur in the HLR;(More)
Although considerable information is available concerning steroidogenesis in the human fetus, the function of the different steroids formed during pregnancy and the factors regulating this delicate hormones balance are poorly understood. During human pregnancy, the placenta synthesizes large quantities of progesterone, estradiol, estrone and estriol and(More)
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