• Publications
  • Influence
Small Molecule–Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease
Drugs that activate integrins inhibit leukocyte recruitment to sites of inflammation. Stimulated to Stop The recruitment of leukocytes from the blood to sites of injury in tissues is mediated byExpand
  • 73
  • 9
  • Open Access
C. elegans detects pathogen-induced translational inhibition to activate immune signaling.
Pathogens commonly disrupt host cell processes or cause damage, but the surveillance mechanisms used by animals to monitor these attacks are poorly understood. Upon infection with pathogenicExpand
  • 139
  • 8
Identification of dendritic antigen-presenting cells in the zebrafish
In mammals, dendritic cells (DCs) form the key link between the innate and adaptive immune systems. DCs act as immune sentries in various tissues and, upon encountering pathogen, engulf and trafficExpand
  • 182
  • 3
  • Open Access
Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants.
Eosinophils are granulocytic leukocytes implicated in numerous aspects of immunity and disease. The precise functions of eosinophils, however, remain enigmatic. Alternative models to study eosinophilExpand
  • 106
  • 2
  • Open Access
Clonal analysis of hematopoietic progenitor cells in the zebrafish.
Identification of hematopoietic progenitor cells in the zebrafish (Danio rerio) has been hindered by a lack of functional assays to gauge proliferative potential and differentiation capacity. ToExpand
  • 48
  • 2
  • Open Access
Caenorhabditis elegans as a model for intracellular pathogen infection
The genetically tractable nematode Caenorhabditis elegans is a convenient host for studies of pathogen infection. With the recent identification of two types of natural intracellular pathogens of C.Expand
  • 48
  • 1
A Wild C. Elegans Strain Has Enhanced Epithelial Immunity to a Natural Microsporidian Parasite
Microbial pathogens impose selective pressures on their hosts, and combatting these pathogens is fundamental to the propagation of a species. Innate immunity is an ancient system that provides theExpand
  • 37
  • 1
  • Open Access
Identification of microsporidia host-exposed proteins reveals a repertoire of rapidly evolving proteins
Pathogens use a variety of secreted and surface proteins to interact with and manipulate their hosts, but a systematic approach for identifying such proteins has been lacking. To identify theseExpand
  • 40
Cell-to-cell spread of microsporidia causes Caenorhabditis elegans organs to form syncytia
The growth of pathogens is dictated by their interactions with the host environment1. Obligate intracellular pathogens undergo several cellular decisions as they progress through their life cyclesExpand
  • 9