Keila E Torres

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Combined Modality Management of Retroperitoneal Sarcomas: A Single-Institution Series of 121 Patients.

A. J. Bishop, Gunar K. Zagars, +4 authors Beverly Ashleigh Guadagnolo
International journal of radiation oncology…
2015

PURPOSE The purpose of this study was to investigate local control, survival outcomes, and complication rates of patients treated with aggressive surgery and radiation therapy (RT) for… (More)

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

Sam Behjati, P. Tarpey, +47 authors Peter J. Campbell
Nature Genetics
2014

Angiosarcoma is an aggressive malignancy that arises spontaneously or secondarily to ionizing radiation or chronic lymphoedema. Previous work has identified aberrant angiogenesis, including… (More)

Universal marker and detection tool for human sarcoma circulating tumor cells.

Arun Satelli, Abhisek Mitra, +10 authors S. L. W. Li
Cancer research
2014

To date, no specific marker exists for the detection of circulating tumor cells (CTC) from different types of sarcomas, though tools are available for detection of CTCs in peripheral blood of… (More)

Clinical Observations and Molecular Variables of Primary Vascular Leiomyosarcoma.

Christina L Roland, Genevieve Marie Boland, +15 authors Keila E Torres
JAMA surgery
2016

IMPORTANCE Vascular leiomyosarcomas are a rare subtype of leiomyosarcomas that most commonly affect the inferior vena cava and account for 5% of all leiomyosarcomas. These tumors are aggressive… (More)

Targeting the PI3K/mTOR axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumors.

Markus PH. Ghadimi, Gonzalo López, +9 authors Dina Chelouche Lev
Molecular cancer therapeutics
2012

There is a critical need for efficacious therapeutic strategies to improve the outcome of patients afflicted by malignant peripheral nerve sheath tumors (MPNST). Multiple lines of evidence suggest a… (More)

Involvement of the PI3K/Akt Pathway in Myxoid/Round Cell Liposarcoma

Elizabeth G Demicco, Keila E Torres, +8 authors Alexander J. F. Lazar
Modern Pathology
2012

The molecular determinants involved in the progression of myxoid liposarcoma to increased cellularity/round cell change are poorly understood. We studied the PI3K/Akt pathway in myxoid and round cell… (More)

Survival After Resection of Gastrointestinal Stromal Tumor and Sarcoma Liver Metastases in 146 Patients

Kristoffer Watten Brudvik, Sameer H. Patel, +7 authors J. Nicholas Vauthey
Journal of Gastrointestinal Surgery
2015

We investigated outcomes by primary tumor type in patients who underwent resection of liver metastases from gastrointestinal stromal tumors (GIST), leiomyosarcomas, and other sarcomas. Our… (More)

Increased H3K9me3 drives dedifferentiated phenotype via KLF6 repression in liposarcoma.

Emily Z. Keung, Kadir Caner Akdemir, +6 authors Lynda Chin
The Journal of clinical investigation
2015

Liposarcoma (LPS) can be divided into 4 different subtypes, of which well-differentiated LPS (WDLPS) and dedifferentiated LPS (DDLPS) are the most common. WDLPS is typically low grade, whereas DDLPS… (More)

Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors.

Keila E Torres, Quan-sheng Zhu, +14 authors Dina Chelouche Lev
Clinical cancer research : an official journal of…
2011

PURPOSE MET signaling has been suggested a potential role in malignant peripheral nerve sheath tumors (MPNST). Here, MET function and blockade were preclinically assessed. EXPERIMENTAL DESIGN… (More)

Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas

Fadzai Chinyengetere, David J. Sekula, +14 authors Ethan Dmitrovsky
BMC Cancer
2015

USP18 (ubiquitin-specific protease 18) removes ubiquitin-like modifier interferon stimulated gene 15 (ISG15) from conjugated proteins. USP18 null mice in a FVB/N background develop tumors as early as… (More)

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