Keiko Mukaida

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We investigated the transition of clinical signs of fulminant-type malignant hyperthermia (f-MH) by analyzing a database consisting of 383 cumulative cases of f-MH from 1961 to 2004. The cases were divided by time period into group 1 (1961–1984), group 2 (1985–1994), and group 3 (1995–2004). The variables considered were age, sex, type of agents used(More)
BACKGROUND Ryanodine receptor 1 (RyR1) is a Ca(2+) release channel located in the sarcoplasmic reticulum membrane of skeletal muscle. More than 200 variants in RyR1 have been identified in DNA from patients with malignant hyperthermia (MH) and congenital myopathies; only 30 have been sufficiently studied so as to be identified as MH-causative mutations. The(More)
Purpose. We compared the results of the in vitro caffeine-halothane contracture test (CHCT) according to the protocols of the North American Malignant Hyperthermia Group (NAMHG) and the European Malignant Hyperthermia Group (EMHG) with the Ca-induced Ca release (CICR) rate test in the same patients with suspected malignant hyper thermia (MH). Methods. Five(More)
Malignant hyperthermia (MH) results from disordered calcium (Ca2+) homeostasis in skeletal muscle during general anesthesia. Although Ca2+ channel blockers may be given to treat the tachycardia and circulatory instability, coadministration of Ca2+ channel blockers and dantrolene is contraindicated during MH crisis. We evaluated the effect of Ca2+ channel(More)
BACKGROUND Malignant hyperthermia (MH) is a potentially fatal complication of general anesthesia triggered by volatile anesthetics. In animal studies, sevoflurane has been reported to be a weak triggering agent. The aim of this study was to evaluate the clinical severity of sevoflurane-induced MH compared to isoflurane. METHODS From the Japanese MH(More)
The efficacy of the McCoy laryngoscope, external laryngeal pressure, and their combination to improve the laryngoscopic view was evaluated in 219 patients and compared with the Macintosh laryngoscope. An experienced laryngoscopist performed laryngoscopy twice using the Macintosh laryngoscope and the McCoy laryngoscope in a random sequence, and external(More)