Learn More
Under anesthesia with N2O (70%) and halothane (2-4%), Purkinje cell activities were extracellularly recorded in the flocculus and nodulus of immobilized pigmented rabbits. Large field (60 degrees x 60 degrees) optokinetic stimulation (OKS) was delivered to the central visual field of one eye with a constant velocity (0.1-4.0 degrees/s) at 0 degrees, 45(More)
The previous electrophysiological study reported that some of the Purkinje cells in the vestibulocerebellum were innervated by branching climbing fibers. To identify the cells of origin of these branching climbing fibers, a pair of retrograde fluorescent tracers, propidium iodide in combination with 4', 6-diamidino-2-phenylindole or diamidino yellow, were(More)
Olivocerebellar branching projections to the flocculus, nodulus and uvula were studied electrophysiologically in pigmented rabbits anesthetized with pentobarbital and halothane. Neurons in the dorsal cap of the inferior olive were antidromically activated by stimulation of the contralateral flocculus, nodulus and uvula. The antidromic responses in the(More)
We cloned a cDNA for the rat mu-opioid receptor from a rat thalamus cDNA library. The deduced amino-acid sequence of rat mu-opioid receptor consists of 398 residues with the features shared by the members of the G-protein coupled receptor family, and is 59% and 60% identical with those of rat kappa-opioid and mouse delta-opioid receptors, respectively.(More)
In immobilized pigmented rabbit anesthetized with N2O (70%) and halothane (2-4%), simple and complex spike responses of Purkinje cells in the cerebellar nodulus to large field optokinetic stimulation (OKS) was studied. About half of the cells showed significant simple spike modulation to OKS delivered to ipsilateral (25/57) or contralateral (18/31) eye. The(More)
Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia among elderly patients. A biomarker for the disease could make diagnosis easier and more accurate, and accelerate drug discovery. In this study, NMR-based metabolomics analysis in conjunction with multivariate statistics was applied to examine changes in urinary metabolites in(More)
We cloned a cDNA for the rat kappa-opioid receptor from a rat thalamus cDNA library. The deduced amino acid sequence consists of 380 residues with features shared by members of the G protein-coupled receptor family. The specific binding of [3H]bremazocine to the membrane of COS-7 cells transfected with the cDNA was displaced by kappa-specific opioid(More)
Leukemia inhibitory factor (LIF) is a pluripotent cytokine which affects the survival and differentiation of various types of cells both in the hematopoietic and nervous systems. In this study, the time course and localization of LIF mRNA expression following kainic acid-induced seizures were examined by northern blot analyses and in situ hybridization.(More)