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Am-80 is a newly snythesized retinoid with the structure of one aromatic amide among retinobenzoic acids. It exhibits specific biological activities of retinoic acid such as the activation of cellular differentiation and proliferation. We investigated the effect of Am-80 on collagen-induced arthritis (CIA) in mice and the immunopharmacological action on the(More)
Experimental allergic encephalomyelitis (EAE) is an autoimmune model with inflammation and demyelination in the central nervous system, which resembles the human demyelinating disorder, multiple sclerosis (MS). In this study, we investigated the effect of Am-80, a synthetic retinoid, on EAE in DA rats. DA rats immunized with complete Freund's adjuvant (CFA)(More)
AIM To observe the role of interleukin (IL)-6 in the development of experimental autoimmune encephalomyelitis (EAE). METHODS DA rats were immunized by injecting bovine myelin basic protein (MBP). mRNA of cytokines, such as IL-6, IL-10, TNF-alpha, TGF-beta 1, IFN-gamma, and iNOS, were detected by RT-PCR. MBP was injected into ear to induce delayed type(More)
ADOPTIVE TRANSFER OF POLYARTHRITIS USING THORACIC DUCT LYMPHOCYTES IN RATS LLslie Cleland, L1ew'CIlyn Spargo, Urahalll Mayrhofer, Ashley Cormolly Arthritis Research l. ... aboratory, Hanson Celltre tor Medieal Research, Adelaide. Australia 5000 Polyarthritis ean be induced in Dark Agollti rats using Freunds Complete Adjuvant (FCA). Virtually 100% of rats(More)
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