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The telomerase activity and length of telomeres of peripheral blood mononuclear cells obtained from 124 healthy individuals aged 4–95years was measured. Telomerase activity level was semiquantitatively assessed by a fluorescent-telomeric repeat amplification protocol (fluorescent-TRAP) using an internal telomerase assay standard, fluorescent primers and an(More)
Simulated Annealing (SA) is an effective general heuristic method for solving many com-binatorial optimization problems. However, SA has two drowbacks. One is the long computational time of the annealings. The other one is the determination of the appropriate temperature schedule in SA. This paper proposes a new parallel SA model(PSA/AT(GA)) which(More)
Helicobacter pylori has recently been postulated to play a role in the pathogenesis of autoimmune diseases, including idiopathic thrombocytopenic purpura (ITP). We investigated the prevalence of H pylori infection and the effects of its eradication in 61 patients with ITP. H pylori infection was found in 50 patients (83%), an incidence significantly higher(More)
We describe a case of hemophagocytic syndrome (HPS) associated with CD8-positive T-cell chronic lymphocytic leukemia (CD8 + T-CLL). A 68-year-old man with CD8 + T-CLL presented with fever, progressive pancytopenia, and lymphadenopathy. Laboratory findings showed a hyper-ferritinemia, abnormalities of coagulation tests, and liver and renal dysfunction with(More)
Dear Editor, A condition marked by fewer than 10% of dysplastic cells and fewer than 5% of blasts in the bone marrow (BM) is now categorized as idiopathic cytopenia of undetermined significance (ICUS); if clonal cytogenetic changes are detectable in ICUS patients, the diagnosis can be changed to myelodysplastic syndrome (MDS) [1]. This categorization is(More)
When simulated annealing (SA) is applied to continuous optimization problems, the design of the neighborhood used in SA becomes important. Many experiments are necessary to determine an appropriate neighborhood range in each problem, because the neighborhood range corresponds to distance in Euclidean space and is decided arbitrarily. We propose multi-point(More)
It is difficult to predict musculoskeletal pain as a withdrawal syndrome following the discontinuation of imatinib (IM) in patients with chronic myeloid leukemia. We investigated a link between physical size and musculoskeletal pain following IM discontinuation. In total, seven out of 24 patients developed musculoskeletal pain after discontinuing IM. Those(More)
We analyzed the exosomal miRNA from peripheral blood from CML patients with musculoskeletal pain after stopping tyrosine kinase inhibitors to identify possible factors related to this manifestation. Exosomal miRNA profiling using TaqMan low-density array revealed that exosomal miR-140-3p was significantly elevated in CML patients showing musculoskeletal(More)