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The telomerase activity and length of telomeres of peripheral blood mononuclear cells obtained from 124 healthy individuals aged 4–95years was measured. Telomerase activity level was semiquantitatively assessed by a fluorescent-telomeric repeat amplification protocol (fluorescent-TRAP) using an internal telomerase assay standard, fluorescent primers and an(More)
Helicobacter pylori has recently been postulated to play a role in the pathogenesis of autoimmune diseases, including idiopathic thrombocytopenic purpura (ITP). We investigated the prevalence of H pylori infection and the effects of its eradication in 61 patients with ITP. H pylori infection was found in 50 patients (83%), an incidence significantly higher(More)
Simulated Annealing (SA) is an effective general heuristic method for solving many combinatorial optimization problems. However, SA has two drowbacks. One is the long computational time of the annealings. The other one is the determination of the appropriate temperature schedule in SA. This paper proposes a new parallel SA model(PSA/AT(GA)) which determines(More)
We describe a case of hemophagocytic syndrome (HPS) associated with CD8-positive T-cell chronic lymphocytic leukemia (CD8 + T-CLL). A 68-year-old man with CD8 + T-CLL presented with fever, progressive pancytopenia, and lymphadenopathy. Laboratory findings showed a hyper-ferritinemia, abnormalities of coagulation tests, and liver and renal dysfunction with(More)
When simulated annealing (SA) is applied to continuous optimization problems, the design of the neighborhood used in SA becomes important. Many experiments are necessary to determine an appropriate neighborhood range in each problem, because the neighborhood range corresponds to distance in Euclidean space and is decided arbitrarily. We propose multi-point(More)
We conducted a questionnaire survey to assess the state of patients with CML after discontinuation of TKI therapy. Nine of 27 patients developed musculoskeletal pain after TKI discontinuation. One had discontinued nilotinib and eight had discontinued imatinib therapy. Median time to symptom development after discontinuation was 2 weeks. Four experienced(More)
Hiroyuki A. Torii,∗1 Y. Morishita,∗2 Y. Yamazaki,∗1,∗2 K. Komaki,∗1 K. Kuroki,∗1 R. Hutton,∗3 K. Ishii,∗4 K. Ando,∗2 H. Masuda,∗5 M. Sekiguchi,∗6 M. Hori,∗7 E. Widmann,∗7 and R. S. Hayano∗7 ∗1 Institute of Physics, University of Tokyo, Komaba Campus ∗2 Atomic Physics Laboratory, RIKEN ∗3 Department of Physics, University of Lund, Sweden ∗4 Department of(More)
We analyzed the exosomal miRNA from peripheral blood from CML patients with musculoskeletal pain after stopping tyrosine kinase inhibitors to identify possible factors related to this manifestation. Exosomal miRNA profiling using TaqMan low-density array revealed that exosomal miR-140-3p was significantly elevated in CML patients showing musculoskeletal(More)