Keiji Noutomi

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RATIONALE Peripheral clock control and the relevance of the circadian rhythm to physiology and disease are major questions in mammalian circadian biology. OBJECTIVE We examined the physiological functions of the liver clock. METHODS AND RESULTS We established a suppressed feeding schedule regimen constituting a high-cholesterol diet delivered every 6(More)
Resetting the peripheral clock and understanding the integration between the circadian rhythm and metabolic pathways are fundamental questions. To test whether insulin acts as a synchronizer for the hepatic clock by cell-autonomous mechanisms, the phase-resetting capabilities of insulin were investigated in cultured hepatic cells. We provide evidence that(More)
Rationale: Peripheral clock control and the relevance of the circadian rhythm to physiology and disease are major questions in mammalian circadian biology. Objective: We examined the physiological functions of the liver clock. Methods and Results: We established a suppressed feeding schedule regimen constituting a high-cholesterol diet delivered every 6(More)
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