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  • Keiichi Hiramatsu, Hideaki Hanaki, T Ino, Konami Yabuta, Toyoko Oguri, Fred C. Tenover
  • Medicine
  • The Journal of antimicrobial chemotherapy
  • 1997 (First Publication: 1 July 1997)
  • (MRSA) with reduced suscept-ibility to vancomycin (MIC 8 mg/L). The strain was isolated from a surgical wound infection which was refrac -tory to vancomycin therapy.In May 1996, a 4 month-old maleExpand
  • Toshihiro Ito, Yuki Katayama, +4 authors Keiichi Hiramatsu
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 2001 (First Publication: 1 May 2001)
  • ABSTRACT The β-lactam resistance gene mecA ofStaphylococcus aureus is carried by a novel mobile genetic element, designated staphylococcal cassette chromosome mec(SCCmec), identified in theExpand
  • Teruyo Ito, Xiao Xue Ma, Fumihiko Takeuchi, Keiko Okuma, Harumi Yuzawa, Keiichi Hiramatsu
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 2004 (First Publication: 1 July 2004)
  • ABSTRACT Staphylococcal cassette chromosome mec (SCCmec) is a mobile genetic element composed of the mec gene complex, which encodes methicillin resistance, and the ccr gene complex, which encodesExpand
  • Yoko Kondo, Teruyo Ito, +4 authors Keiichi Hiramatsu
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 2006 (First Publication: 16 October 2006)
  • ABSTRACT Staphylococcal cassette chromosome mec (SCCmec) typing, in combination with genotyping of the Staphylococcus aureus chromosome, has become essential for defining methicillin-resistant S.Expand
  • Yoshinori Katayama, Toshihiro Ito, Keiichi Hiramatsu
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 2000 (First Publication: 1 June 2000)
  • ABSTRACT We have previously shown that the methicillin-resistance genemecA of Staphylococcus aureus strain N315 is localized within a large (52-kb) DNA cassette (designated the staphylococcalExpand
  • Makoto Kuroda, Hiroko Kuroda, Taku Oshima, Fumihiko Takeuchi, Hirotada Mori, Keiichi Hiramatsu
  • Medicine, Biology
  • Molecular microbiology
  • 2003 (First Publication: 28 January 2004)
  • DNA microarray covering the whole genome of Staphylococcus aureus strain N315 was prepared to investigate transcription profiles. The microarray analyses revealed that vancomycin inducesExpand