Kei Miyamoto

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STUDY DESIGN In vitro studies on the effects of recombinant human growth and differentiation factor-5 (rhGDF-5) on matrix metabolism of bovine intervertebral disc cells and an in vivo study on the effect of rhGDF-5 in the rabbit anular puncture model. OBJECTIVE To determine the reparative capacity of rhGDF-5 on the intervertebral disc. SUMMARY OF(More)
STUDY DESIGN A retrospective analysis was performed of the clinical outcomes of patients with pyogenic or tuberculotic spondylitis who were treated with two-stage surgery (first stage: placement of posterior instrumentation; second stage: anterior debridement and bone grafting). OBJECTIVE To evaluate the clinical outcomes of the abovementioned two-stage(More)
Amphibian oocytes can rapidly and efficiently reprogram the transcription of transplanted somatic nuclei. To explore the factors and mechanisms involved, we focused on nuclear actin, an especially abundant component of the oocyte's nucleus (the germinal vesicle). The existence and significance of nuclear actin has long been debated. Here, we found that(More)
STUDY DESIGN A prospective study on the clinical outcomes in patients with tuberculous spondylitis treated by a 2-stage operation (posterior and anterior) using posterior spinal instrumentation. OBJECTIVE To evaluate the clinical outcomes of the 2-stage surgical treatment (first stage: placement of posterior instrumentation and second stage: anterior(More)
STUDY DESIGN A comparative study of aggrecanases and aggrecan fragmentation profile in the human intervertebral disc at early and advanced stages of disc degeneration. OBJECTIVE To determine differences in the content of the aggrecanases and the profile of aggrecan fragmentation in early and advanced stages of disc degeneration using cadaveric human(More)
BACKGROUND CONTEXT Although posterior lumbar interbody fusion (PLIF) for degenerative lumbar diseases is routine, there are few reports on double-level PLIF. PURPOSE To evaluate the clinical outcomes of double-level PLIF. STUDY DESIGN/SETTING A retrospective study of operated cases in Gifu, Japan. PATIENT SAMPLE Nineteen patients (8 men and 11 women,(More)
STUDY DESIGN Retrospective study of clinical outcomes of 1-staged combined cervical and lumbar decompression for patients with tandem spinal stenosis (TSS). OBJECTIVE To describe middle-term clinical outcomes of this procedure. SUMMARY AND BACKGROUND DATA Little is known with regard to the clinical outcomes of 1-staged combined cervical and lumbar(More)
STUDY DESIGN The reliabilities of and correlations among 5 standard methods of assessing cervical sagittal alignment were evaluated. OBJECTIVE To investigate the reliabilities of and correlations among 5 standard methods of assessing cervical sagittal alignment. SUMMARY OF BACKGROUND DATA Although various cervical sagittal alignment assessment methods(More)
Although cervical anterior osteophytes accompanying diffuse idiopathic skeletal hyperostosis (DISH) are generally asymptomatic, large osteophytes sometimes cause swallowing disorders. Surgical resection of the osteophyte has been reported to be an effective treatment; however, little study has been given to the recurrences of osteophytes. A prospective(More)
Nuclear transfer has been regarded as the only reliable tool for studying nuclear reprogramming of mammalian somatic cells by oocytes. However, nuclear transfer is not well suited for biochemical analyses of the molecular mechanisms of reprogramming. A cell-free system from oocytes is an attractive alternative way to mimic reprogramming in vitro, since a(More)