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STUDY DESIGN Consecutive case series and literature review. OBJECTIVE To describe the utility of 3-dimensional computed tomographic angiography (3D CTA) for evaluating vertebral artery (VA) anomalies before surgery. SUMMARY OF BACKGROUND DATA Recent advances in instrumentation surgery at the craniovertebral junction (CVJ) enable us to perform rigid(More)
BACKGROUND The aim of this study was to determine the prognostic value of peritumoral deposits (PTDs) in colorectal cancer (CRC). METHODS A total of 695 patients with pT3/T4 CRC (1980 to 1999) were reviewed. Tumor deposits located ≥2 mm from the front of the direct spread in the primary tumor were evaluated as PTDs. RESULTS PTDs were observed in 111(More)
We aimed to determine semiquantitative evaluation criteria for Crohn-like lymphoid reaction (CLR). We reviewed 1,032 patients with colorectal cancer and evaluated CLR by counting all peritumoral lymphoid aggregates (LAs) and by measuring the maximum diameter of the largest LA. The maximum diameter of the largest LA, rather than the number, had a significant(More)
Granulocyte colony-stimulating factor (G-CSF) is a cytokine that is clinically used to treat neutropenia. G-CSF also has non-hematopoietic functions and could potentially be used to treat neuronal injury. To confirm the safety and feasibility of G-CSF administration for acute spinal cord injury (SCI), we have initiated a phase I/IIa clinical trial of(More)
STUDY DESIGN Retrospective clinical study. OBJECTIVE To report the surgical outcomes of patients with cervical myelopathy associated with athetoid cerebral palsy and to assess whether a halo vest is necessary for postoperative external immobilization. SUMMARY OF BACKGROUND DATA Although a halo vest has remained the first choice for postoperative(More)
Based on the neuroprotective effects of granulocyte colony-stimulating factor (G-CSF) on experimental spinal cord injury, we initiated a clinical trial that evaluated the safety and efficacy of neuroprotective therapy using G-CSF for patients with worsening symptoms of compression myelopathy. We obtained informed consent from 15 patients, in whom the(More)
Granulocyte colony-stimulating factor (G-CSF) mobilizes peripheral blood stem cells (PBSCs) derived from bone marrow. We hypothesized that intraspinal transplantation of PBSCs mobilized by G-CSF could promote functional recovery after spinal cord injury. Spinal cords of adult nonobese diabetes/severe immunodeficiency mice were injured using an Infinite(More)
STUDY DESIGN An open-labeled multicenter prospective nonrandomized controlled clinical trial. OBJECTIVE To confirm the feasibility of using granulocyte colony-stimulating factor (G-CSF) for treatment of acute spinal cord injury (SCI). SUMMARY OF BACKGROUND DATA We previously reported that G-CSF promotes functional recovery after compression-induced SCI(More)
STUDY DESIGN An open-labeled multicenter prospective controlled clinical trial. OBJECTIVE To confirm the feasibility of granulocyte colony-stimulating factor (G-CSF) administration for patients with thoracic myelopathy. SUMMARY OF BACKGROUND DATA Although G-CSF is best known as an important cytokine commonly used to treat neutropenia, it also has(More)