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Involvement of the Phosphatidylinositol 3-Kinase/Rac1 and Cdc42 Pathways in Radial Migration of Cortical Neurons*
During cortical development, newly generated neurons migrate radially toward their final positions. Although several candidate genes essential for this radial migration have been reported, theExpand
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
Neural networks are balanced by inhibitory and excitatory neuronal activity. The formation of these networks is initially generated through neuronal subtype specification controlled by transcriptionExpand
Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis.
Mutations in the Autism susceptibility candidate 2 gene (AUTS2), whose protein is believed to act in neuronal cell nuclei, have been associated with multiple psychiatric illnesses, including autismExpand
Spatiotemporal fate map of neurogenin1 (Neurog1) lineages in the mouse central nervous system
Neurog1 (Ngn1, Neurod3, neurogenin1) is a basic helix‐loop‐helix (bHLH) transcription factor essential for neuronal differentiation and subtype specification during embryogenesis. Due to theExpand
Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord
PTF1-J is a trimeric transcription factor complex essential for generating the correct balance of GABAergic and glutamatergic interneurons in multiple regions of the nervous system, including theExpand
NMDA Receptor-Dependent Synaptic Translocation of Insulin Receptor Substrate p53 via Protein Kinase C Signaling
The activity-dependent remodeling of postsynaptic structure is a fundamental process underlying learning and memory. Insulin receptor substrate p53 (IRSp53), a key player in cytoskeletal dynamics, isExpand
Differential modulation of NR1‐NR2A and NR1‐NR2B subtypes of NMDA receptor by PDZ domain‐containing proteins
The PSD‐95/Dlg/ZO‐1 (PDZ) domain‐containing proteins MALS and PSD‐95 localize to post‐synaptic densities and bind the COOH‐termini of NR2 subunits of the NMDA receptor. The effects of MALS‐2 andExpand
MALS is a binding partner of IRSp53 at cell–cell contacts
Insulin receptor substrate p53 (IRSp53) is a key player in cytoskeletal dynamics, interacting with the actin modulators WAVE2 and Mena. Here, we identified a PDZ protein, MALS, as anExpand
Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.
Proprioception, the sense of limb and body position, is essential for generating proper movement. Unconscious proprioceptive information travels through cerebellar-projecting neurons in the spinalExpand
A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord.
Dorsal horn neurons express many different neuropeptides that modulate sensory perception like the sensation of pain. Inhibitory neurons of the dorsal horn derive from postmitotic neurons thatExpand