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A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
The requirement for a Ptf1a-Rbpj complex in controlling the balanced formation of inhibitory and excitatory neurons in the developing spinal cord is demonstrated, and a novel Notch-independent function for Rbpj in nervous system development is pointed to.
Involvement of the Phosphatidylinositol 3-Kinase/Rac1 and Cdc42 Pathways in Radial Migration of Cortical Neurons*
- D. Konno, Saori Yoshimura, Kei Hori, Hisato Maruoka, K. Sobue
- BiologyJournal of Biological Chemistry
- 11 February 2005
The results suggest that both the PI 3-kinase/Rac1 and Cdc42 pathways are involved in the radial migration of cortical neurons and that they have different roles.
Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis.
NMDA Receptor-Dependent Synaptic Translocation of Insulin Receptor Substrate p53 via Protein Kinase C Signaling
- Kei Hori, H. Yasuda, D. Konno, Hisato Maruoka, T. Tsumoto, K. Sobue
- BiologyThe Journal of Neuroscience
- 9 March 2005
It is reported here that IRSp53 is accumulated rapidly at the postsynaptic sites of cultured hippocampal neurons after glutamate or NMDA stimulation in an actin cytoskeleton-dependent manner, and this data suggest that IR sp53 is involved in NMDA receptor-linked synaptic plasticity via PKC signaling.
Spatiotemporal fate map of neurogenin1 (Neurog1) lineages in the mouse central nervous system
This study provides the first overview of the spatiotemporal fate map of Neurog1 lineages in the central nervous system and identifies multiple exceptions including Purkinje cells and other GABAergic neurons in the cerebellum.
Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord
Neurog2 expression is directly regulated by the PTF1-J complex, identifying Neurog2 as the first neural target of Ptf1a and revealing a bHLH transcription factor cascade functioning in the specification of GABAergic neurons in the dorsal spinal cord and cerebellum.
A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord.
MALS is a binding partner of IRSp53 at cell–cell contacts
Differential modulation of NR1‐NR2A and NR1‐NR2B subtypes of NMDA receptor by PDZ domain‐containing proteins
- Takashi Iwamoto, Yasue Yamada, Kei Hori, Yoshifumi Watanabe, K. Sobue, M. Inui
- BiologyJournal of neurochemistry
- 1 April 2004
The results indicate that the NR1‐NR2A and NR1-NR2B receptors are modulated differentially by MALS‐2 and PSD‐95, and that similar regulatory effects of PSD-95 on these receptors are achieved by distinct mechanisms.