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PURPOSE In a rat model of retinopathy of prematurity (ROP), the retinal vasculature and function of the neural retina were studied longitudinally. Vascular and neural parameters were evaluated for significant relationships. METHODS Retinopathy was induced by exposing newborn rats to alternating 50% and 10% oxygen until age 14 days. To evaluate the(More)
PURPOSE To study the development of the electroretinographic (ERG) oscillatory potentials (OPs) in rats and to compare normal OPs with those in a rat model of retinopathy of prematurity (ROP). METHODS Following a longitudinal design, ERG responses to a greater than 5 log unit range of full-field stimuli were recorded in dark-adapted rats at postnatal day(More)
BACKGROUND To evaluate the safety of the scleral collagen cross-linking (CXL) transferred from corneal CXL in rabbit eyes using histology and electroretinography (ERG). METHODS Stress-strain measurement was performed five rabbits 1 week after scleral CXL. Dark-adapted ERG was repeatedly applied on bilateral eyes of 10 rabbits before, and 1 week, 1 month(More)
PURPOSE To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area of the optic nerve head. METHODS This experimental study included nine monkeys that underwent implantation of a lumbar-peritoneal cerebrospinal fluid (CSF) shunt. In the study group (n = 4(More)
PURPOSE To evaluate the ability of increased expression of brain-derived neurotrophic factor (BDNF) using adenoassociated viral (AAV) vector to prevent the loss of rat retinal ganglion cells (RGCs) and visual function after acute elevation of intraocular pressure (IOP). METHODS AAV vectors (expressing BDNF or GFP) were injected into the vitreous 6 hours(More)
Rabbit right eyes were injected with 3 or 6 mg ketorolac tromethamine into the suprachoroidal space. Electroretinography results demonstrated no abnormal changes in rod cell response, maximum rod cell or cone cell mixing reaction, oscillation potential, cone cell response, waveform, amplitude, and potential of 30 Hz scintillation response in right eyes(More)
PURPOSE We evaluated repeatability and reproducibility of measurements of the retinal nerve fiber layer thickness (RNFLT), optic nerve head (ONH), and macular inner retinal layer (MIRL) by RTVue spectral-domain optical coherence tomography (OCT) in normal Rhesus monkeys. METHODS The experimental study included 15 adult Rhesus macaque monkeys. RNFLT, ONH(More)
PURPOSE To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) as compared to elevated intraocular pressure (IOP) on axonal morphology and axonal motor proteins in retinal ganglion cells (RGCs). METHODS The experimental study included 39 rats which underwent cerebrospinal fluid drainage for 6 hr, 30 rats which unilaterally(More)
Hamid Abdollahi Heidi Abrahamse Geraldo Abreu Václava Adámková H Lee Adamo Hermann Agis Gulsah Akin Hakan Akin Cassio Alencar Ana Lŭcia Almeida Delilah Alonso Leticia Alvarenga Ana Andabak Rogulj Juanita Anders Sebastiano Andreana Akira Aoki Praveen Arany Wanessa Aras Patricia Armati Cem Atabey O. Sahap Atik Rodolfo Avila Ivona Bago Anja Baraba G. Baxter(More)