Keewoong Jang

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OBJECTIVE Hypocellularity resulting from chondrocyte death in the aftermath of mechanical injury is thought to contribute to posttraumatic osteoarthritis. However, we observed that nonviable areas in cartilage injured by blunt impact were repopulated within 7-14 days by cells that appeared to migrate from the surrounding matrix. The aim of this study was to(More)
The accuracy of quantitative real-time RT-PCR (qRT-PCR) is often influenced by experimental artifacts, resulting in erroneous expression profiles of target genes. The practice of employing normalization using a reference gene significantly improves reliability and its applicability to molecular biology. However, selection of an ideal reference gene(s) is of(More)
There is a need to develop mechanically active culture systems to better understand the role of mechanical stresses in intervertebral disc (IVD) degeneration. Motion segment cultures that preserve the native IVD structure and adjacent vertebral bodies are preferred as model systems, but rapid ex vivo tissue degeneration limits their usefulness. The(More)
We recently introduced a novel pluronic F127 and hyaluronic acid-based hydrogel (HG) designed to deliver a broad range of therapeutics. The reverse-thermal responsive HG exhibits physical properties that seem to be ideal for the local delivery of drug- and cell-based therapies to specific anatomic sites through percutaneous injection. However, questions(More)
Depending on the damage extent and adjacent tissue condition in traumatic cartilage injury, it is possible to heal the tissue by resident cells. Unlike autologous chondrocyte implantation, short-term enzymatic treatment is an effective single-step procedure without extra cell expansion. Moreover, this method has been shown to significantly increase(More)
ii ACKNOWLEDGEMENTS I would like to acknowledge sincerely to my committee members, my coworkers, my family and friends, without whom this thesis would not be completed. First of all, I would like to extend my heartfelt gratitude to my research advisor, Dr. James Martin, without whom I could not finish this thesis. His outstanding originality, active(More)
Recommended Citation Yu, Yin. "Identification and characterization of cartilage progenitor cells by single cell sorting and cloning. ii ACKNOWLEDGEMENTS This thesis would not have been possible without the guidance of my committee members, help from my colleagues and friends, and support from my family. First and Foremost, I would like to express my deepest(More)
ii To my family, wife iii ACKNOWLEDGEMENTS First of all, I thank God for allowing me to be here today after several years of study at the University of Iowa. I cannot express enough thanks to my committee for their continued support and encouragement: my sincere appreciation for all the learning opportunities given to me provided by my committee. I extend(More)
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