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Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity.
Aggressive tumor growth, diffuse tissue invasion, and neurodegeneration are hallmarks of malignant glioma. Although glutamate excitotoxicity is considered to play a key role in glioma-inducedExpand
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  • 3
  • Open Access
mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.
Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with no harmful effectsExpand
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Role of hypothalamus in aging and its underlying cellular mechanisms
  • Keetae Kim, H. Choe
  • Biology, Medicine
  • Mechanisms of Ageing and Development
  • 31 January 2019
Aging is characterized by a progressive loss of several physiological functions that can cause various age-related disorders. Several factors have been identified as causes of aging to elucidate theExpand
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Characterization of a novel cyclin-dependent kinase 1 inhibitor, BMI-1026.
Cyclin-dependent kinases (Cdks) have been attractive targets for the development of anticancer therapeutic agents. In an effort to generate a new class of anti-Cdk inhibitors, we synthesized arylExpand
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  • Open Access
Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation
SUMMARY Obesity-associated metabolic alterations are closely linked to low-grade inflammation in peripheral organs, in which macrophages play a central role. Using genetic labeling of myeloid lineageExpand
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Regulation of longevity by regulator of G‐protein signaling protein, Loco
Regulator of G‐protein signaling (RGS) proteins contribute to G‐protein signaling pathways as activators or repressors with GTPase‐activating protein (GAP) activity. To characterize whetherExpand
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MicroRNAs in brain aging
Brain aging is one of the most crucial biological processes that affect the physiological balance between health and disease. Age-associated dysfunction of brain leads to severe health problems inExpand
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A Mercaptoacetamide‐Based Class II Histone Deacetylase Inhibitor Suppresses Cell Migration and Invasion in Monomorphic Malignant Human Glioma Cells by Inhibiting FAK/STAT3 Signaling
  • J. Nam, H. Cho, +5 authors H. Hoe
  • Medicine, Biology
  • Journal of cellular biochemistry
  • 1 December 2017
Histone deacetylase inhibitors (HDACIs) have emerged as potential anticancer agents for the treatment of solid and hematopoietic cancers. Several HDACIs delay cell growth, induce differentiation, orExpand
  • 11
Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons.
Dendrite aberration is a common feature of neurodegenerative diseases caused by protein toxicity, but the underlying mechanisms remain largely elusive. Here, we show that nuclear polyglutamineExpand
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  • Open Access
Tumor vasodilation by N-Heterocyclic carbene-based nitric oxide delivery triggered by high-intensity focused ultrasound and enhanced drug homing to tumor sites for anti-cancer therapy.
Nitric oxide (NO) is widely known as an effective vasodilator at low concentrations. Drug delivery systems combined with NO can dilate blood vessels surrounding tumor tissues, and the drugExpand
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