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BACKGROUND Deliberate self-harm among young people is an important focus of policy and practice internationally. Nonetheless, there is little reliable comparative international information on its extent or characteristics. We have conducted a seven-country comparative community study of deliberate self-harm among young people. METHOD Over 30,000 mainly(More)
This study aimed at determining the functional neuroanatomy of mental pain, a hitherto neglected symptom in the study of depression, which according to DSM-IV is stronglylinked with suicide. Mental pain (measured with the Orbach & Mikulincer Mental Pain Scale), suicidal ideation (measured using the Hamilton Rating Scale for Depression), hopelessness(More)
PURPOSE OF REVIEW To review literature on young people who deliberately harmed themselves that was published between March 2005 and December 2006 in English language journals. RECENT FINDINGS Recent follow-up studies have confirmed that deliberate self-harm at a young age is an important indication of mental health problems in later life, including a(More)
BACKGROUND Bereaved individuals are at increased risk of mental and physical disorders, and prevention and treatment of complicated grief is indicated. Earlier quantitative reviews have not focused on the effect of bereavement interventions on (complicated) grief. Therefore the main objective of this meta-analysis was to determine the short-term and(More)
BACKGROUND Depression has a reported mean prevalence of 24% in patients diagnosed with cancer. However, little systematic research on the efficacy of antidepressants in patients with cancer has been performed. METHOD The efficacy and safety of mianserin were studied in 55 depressed women with breast cancer (stage I or II and without known metastases), in(More)
BACKGROUND Psycho-educational programs are among the most commonly applied suicide prevention approaches for young people. This study examined the effectiveness of these programs in a controlled study by assessing the effect on knowledge, attitudes, coping and hopelessness. METHOD Fourteen- to 18-year-old students were administered structured(More)
OBJECTIVE We conducted meta-analyses of functional and structural neuroimaging studies comparing adolescent and adult individuals with a history of suicidal behavior and a psychiatric disorder to psychiatric controls in order to objectify changes in brain structure and function in association with a vulnerability to suicidal behavior. METHODS Magnetic(More)
This study aimed to investigate the feasibility of brain single-photon emission tomography (SPET) in the letter and category fluency paradigm of the Controlled Oral Word Association (COWA) test in healthy volunteers. Two groups each comprising ten right-handed healthy volunteers were injected twice with 370 MBq technetium-99m ethyl cysteinate dimer(More)
OBJECTIVE To investigate the current state of knowledge regarding the neurobiology of suicide and suicidality. METHOD The literature on the neurobiology of suicidality and suicide was reviewed. RESULTS There is clear evidence that the activity of 3 neurobiological systems has a role in the pathophysiology of suicidal behaviour. This includes(More)
This study investigated the feasibility of brain single photon emission computed tomography (SPECT) functional imaging in a neuropsychological test setting, following a single-day protocol with a split-dose paradigm. The Stroop Color Word Test (SCWT) is an example of a well-documented prefrontal activation task. In a split-dose protocol, ten right-handed(More)