Keerthana Ravichandran

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Hermansky-Pudlak syndrome (HPS) is a group of disorders characterized by the malformation of lysosome-related organelles, such as pigment cell melanosomes. Three of nine characterized HPS subtypes result from mutations in subunits of BLOC-2, a protein complex with no known molecular function. In this paper, we exploit melanocytes from mouse HPS models to(More)
Melanosomes are a type of lysosome-related organelle that is commonly defective in Hermansky-Pudlak syndrome. Biogenesis of melanosomes is regulated by BLOC-1, -2, -3, or AP-1, -3 complexes, which mediate cargo transport from recycling endosomes to melanosomes. Although several Rab GTPases have been shown to regulate these trafficking steps, the precise(More)
The mangroves of the Andaman and Nicobar Islands (ANI) are recognized as the best in the country in terms of density and growth. However, considerable disparities still exist in the species composition and classification of mangrove species in the ANI. Further, taxonomical identity and occurrence of certain mangrove species in the ANI remain imprecise.(More)
Rhizophoramucronatavar.alokii (Rhizophoraceae), a new variety of Rhizophora from the Andaman and Nicobar Islands, India, is described and illustrated. The new variety is remarkable in having four stamens, laterally folded leaves, a short peduncle, thick leathery petals, and a four-sided ovary with a sessile style. A key for the species of Rhizophora of the(More)
Cytotoxic T lymphocytes patrol our body in search for infected cells which they kill through the release of cytotoxic substances contained in cytotoxic granules. The fusion of cytotoxic granules occurs at a specially formed contact site, the immunological synapse, and is tightly controlled to ensure specificity. In this review, we discuss the contribution(More)
A method is presented to determine the forced responses of piezoelectric cylinders using weighted sums of only certain exact solutions to the equations of motion and the Gauss electrostatic conditions. One infinite set of solutions is chosen such that each field variable is expressed in terms of Bessel functions that form a complete set in the radial(More)
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