Keele E. Wurst

Learn More
The purpose of the study was to examine how patient sources of antidepressant information were related to antidepressant adherence. Eight community pharmacies in central North Carolina participated in the study. A research assistant interviewed eighty-one English-speaking patients who were picking up antidepressant refill prescriptions. Patients most(More)
BACKGROUND Several studies have evaluated maternal first trimester paroxetine use and the prevalence of congenital defects, particularly cardiac defects. To synthesize current epidemiologic information, a meta-analysis was conducted. METHODS A systematic literature search was conducted for original research published from January 1, 1992, through(More)
BACKGROUND Children with sickle cell disease (SCD) aged <5 years are at great risk for invasive infection with Staphylococcus pneumoniae and Haemophilus influenzae due to the inability of their spleen to protect against infection. OBJECTIVES This study examined (1) physicians' perceptions of factors associated with adherence to antibiotic prophylaxis in(More)
Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) is a loosely-defined clinical entity referring to patients who exhibit characteristics of both asthma and chronic obstructive pulmonary disease (COPD). Clinical definitions and classifications for ACOS vary widely, which impacts our understanding of prevalence, diagnosis and treatment of(More)
BACKGROUND As part of an effort to validate the General Practice Research Database (GPRD) for future studies of medication use in pregnancy, this study examined whether the rates of all, and specific types of, congenital heart defects obtained from the GPRD are similar to those obtained from UK national systems. METHODS The prevalence rates of heart(More)
BACKGROUND Although Hispanics constitute the most rapidly growing ethnic group in the United States, few studies have examined the relationship between Hispanic ethnicity and patients' experiences with the use of antidepressant medications. OBJECTIVE The purpose of this study was to examine the influence of Hispanic ethnicity on patients' expression of(More)
RATIONALE To assess the treatment progression during the 24 months following a formal diagnosis of chronic obstructive pulmonary disease (COPD) in the UK primary care setting. METHODS A retrospective cohort of newly diagnosed COPD patients was identified in the Clinical Practice Research Datalink (CPRD) from 1/1/2008 until 31/12/2009. Maintenance therapy(More)
OBJECTIVE The purpose of this research was (1) to validate that ventricular septal defect (VSD), tetralogy of Fallot (TOF), and coarctation of the aorta (COA) can be studied in the UK General practice research database (GPRD) and (2) to understand which of the available GPRD components (computerized medical records, questionnaires, and maternal/infant free(More)