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BACKGROUND Skin cancer is the most common cancer throughout the world. The epithelial-mesenchymal transition (EMT) and the acquisition of cancer stem cells (CSCs)-like properties emerge as critical steps in the metastasis of human skin cancers. Caffeic acid (CaA) exerts anticarcinogenic effects. However, the effects of CaA on the migratory capability and on(More)
OBJECTIVE To study the effect of copper deficiency on the nutritional status of iron, the expression of hepcidin mRNA and transferrin receptor mRNA in rats. METHODS Forty eight clean male SD rats were randomly divided into four groups according to body weight; and there were 12 rats in each group. The groups are normal iron and copper control group (group(More)
OBJECTIVE To study the effect of iron deficiency on vitamin A (VA) metabolism in rats. METHODS Forty-four male SD rats were divided randomly into four groups according to their body weights and every group included 11 rats: control group (I group), entire iron deficient and normal VA group (II group), slight iron deficient and normal VA group (III group),(More)
To improve the half-life and tissue targeting of superoxide dismutase (SOD) in suppressing reactive oxygen species (ROS)-mediated injury, SOD was chemically modified with N,N,N-trimethyl chitosan chloride (TMC) to generate TMC-SOD. In this study, the pharmacokinetics of TMC-SOD had been studied. 125I-radiolabeled TMC-SOD conjugate was administered to(More)
OBJECTIVE To study the influence of atRA on iron metabolism in cultured primary rat hepatocyte. METHODS Rat primary hepatocytes were isolated by two-step in situ collagenase perfusion method by Seglen, and after that Cell viability was observed by 0.4% trypan blue. And then primary hepatocyte were treated into 6 wells plate with 0, 0.5, 1 and 50(More)
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