Ke-xiang Zhao

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Diabetic encephalopathy is clinically characterized by acquired behavior and cognitive dysfunction but its pathogenesis is not clear. This study aimed to explore the pathogenesis of diabetic encephalopathy and the mechanisms of ghrelin to ameliorate cognitive dysfunction in diabetic rats. Thirty-six streptozotocin diabetic rat models were established; 12(More)
Diabetes mellitus (DM) is associated with cognitive deficits and an increased risk of Alzheimer's disease (AD). Recently, a newly identified heptapeptide of the renin-angiotensin system (RAS), angiotensin-(1-7) [Ang-(1-7)], was found to protect against brain damage. This study investigated the effects of Ang-(1-7) on diabetes-induced cognitive deficits.(More)
Cognitive impairment has been a common complication of diabetic. Recent evidences have pointed out angiotensin-IV (Ang-IV) can facilitate memory acquisition and recovery, whether it also can improve cognitive functions of diabetic rats with cognition disorder and the possible mechanisms if it really can are yet unknown. In this study, 45 Sprague Dawley (SD)(More)
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