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—Universal approximation is the basis of theoretical research and practical applications of fuzzy systems. Studies on the universal approximation capability of fuzzy systems have achieved great progress in recent years. In this paper, linear Takagi–Sugeno (T–S) fuzzy systems that use linear functions of input variables as rule consequent and their special(More)
OBJECTIVE Emerging evidence suggests that microRNA (miRNA)-mediated gene regulation influences a variety of autoimmune disease processes, including Crohn's disease (CD), but the biological function of miRNAs in CD remains unclear. We examine miRNA level in colon tissues and study the potential functions of miRNAs that regulate pathological genes during the(More)
Fluorescence imaging of nitric oxide (NO) in vitro and in vivo is essential to developing our understanding of the role of nitric oxide in biology and medicine. Current probes such as diaminofluorescein depend on reactions with oxidized NO products, but not with nitric oxide directly, and this limits their applicability. Here we report the formation of an(More)
BACKGROUND AND AIMS Tumour necrosis factor alpha (TNFalpha) is a focal point of the inflammatory cascade in Crohn's disease (CD). As an emerging approach to block cytokines, antisense oligonucleotide (ASO) has developed quickly, but is thwarted by a key obstacle-safe and effective delivery to specified cells. Here a novel nano-complex, based on(More)
To evaluate the different traits of mesenchymal stem cell (MSC) isolated from osteosarcoma (OS) and normal bone marrow (BM) induced by bone-morphogenetic protein-2 (BMP-2). MSCs from implanted osteosarcoma or femur bone marrow were isolated and cultured. Differentiation potency was verified and phenotypes were evaluated by flow cytometry. Increased or(More)
As neural data are generally noisy, artifact rejection is crucial for data preprocessing. It has long been a grand research challenge for an approach which is able: 1) to remove the artifacts and 2) to avoid loss or disruption of the structural information at the same time, thus the risk of introducing bias to data interpretation may be minimized. In this(More)
BACKGROUND Results from published studies on the association of donor or recipient TNF-A -308G/A polymorphism with acute rejection (AR) of renal allograft are inconsistent. We performed a meta-analysis to summarize the possible association. METHODS Studies were identified by searching PUBMED, EMBASE and Chinese National Knowledge Infrastructure (CNKI)(More)