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Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
The elucidation of factors that activate the regeneration of the adult mammalian heart is of major scientific and therapeutic importance. Here we found that epicardial cells contain a potent… Expand
APJ ACTS AS A DUAL RECEPTOR IN CARDIAC HYPERTROPHY
Cardiac hypertrophy is initiated as an adaptive response to sustained overload but progresses pathologically as heart failure ensues. Here we report that genetic loss of APJ, a G-protein-coupled… Expand
The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction.
Regeneration of the damaged myocardium is one of the most challenging fronts in the field of tissue engineering due to the limited capacity of adult heart tissue to heal and to the mechanical and… Expand
Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment.
A critical but molecularly uncharacterized step in heart formation and regeneration is the process that commits progenitor cells to differentiate into cardiomyocytes. Here, we show that the… Expand
A Nodal-to-TGF&bgr; Cascade Exerts Biphasic Control Over Cardiopoiesis
- Wenqing Cai, Rosa M. Guzzo, Ke Wei, E. Willems, H. Davidovics, M. Mercola
- Biology, Medicine
- Circulation research
- 14 September 2012
Rationale: The transforming growth factor-&bgr; (TGF&bgr;) family member Nodal promotes cardiogenesis, but the mechanism is unclear despite the relevance of TGF&bgr; family proteins for myocardial… Expand
Heparan sulfate glycosaminoglycans modulate migration and survival in zebrafish primordial germ cells.
Early in embryonic development, primordial germ cells (PGCs) are specified and migrate from the site of their origin to where the gonad develops, following a specific route. Heparan sulfate… Expand
miRNAs that Induce Human Cardiomyocyte Proliferation Converge on the Hippo Pathway
SUMMARY Understanding the mechanisms that control human cardiomyocyte proliferation might be applicable to regenerative medicine. We screened a whole genome collection of human miRNAs, identifying 96… Expand
Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale‐up for high content screening
Background. Blood vessel formation is important for many physiological and pathological processes and is therefore a critical target for drug development. Inhibiting angiogenesis to starve a tumour… Expand
Protein Corona Influences Cell-Biomaterial Interactions in Nanostructured Tissue Engineering Scaffolds.
- Vahid Serpooshan, M. Mahmoudi, +11 authors P. Ruiz-Lozano
- Materials Science, Medicine
- Advanced functional materials
- 1 July 2015
Biomaterials are extensively used to restore damaged tissues, in the forms of implants (e.g. tissue engineered scaffolds) or biomedical devices (e.g. pacemakers). Once in contact with the… Expand
Use of bio-mimetic three-dimensional technology in therapeutics for heart disease
Due to the limited self-renewal capacity of cardiomyocytes, the mammalian heart exhibits impaired regeneration and insufficient ability to restore heart function after injury. Cardiovascular tissue… Expand