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A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements and the function of external sphincters, with corresponding preservation of motor neurons in the brainstem oculomotor nuclei, and of Onuf's nucleus in the sacral spinal cord. Studying the differences in properties of neurons that are vulnerable and resistant(More)
Phosphatase and tensin homolog (PTEN), a negative regulator of the mammalian target of rapamycin (mTOR) pathway, is widely involved in the regulation of protein synthesis. Here we show that the PTEN protein is enriched in cell bodies and axon terminals of purified motor neurons. We explored the role of the PTEN pathway by manipulating PTEN expression in(More)
Gene expression profiling has been used previously with spinal cord homogenates and laser capture microdissected motor neurons to determine the mechanisms involved in neurodegeneration in amyotrophic lateral sclerosis. However, while cellular and animal model work has focused on superoxide dismutase 1-related amyotrophic lateral sclerosis, the(More)
Innovation provides the means for enterprises to survive and grow. Due to the distributed and heterogeneous characteristics, it's difficult to manage innovation across the extended enterprise. A novel vision for Semantic Innovation Management (SIM) is introduced. The system architecture combines ontology, inference and mediation technologies used to create(More)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment to date. Despite its multi-factorial aetiology, oxidative stress is hypothesized to be one of the key pathogenic mechanisms. It is thus proposed that manipulation of the expression of antioxidant genes that are downregulated in the presence of mutant(More)
Business process collaboration is one of the most significant factors driving today's global business development. Researches and applications such as business process modeling, workflow interoperability, web service and ambient intelligence have been involved in this area. However, a holistic understanding is missing. To clarify the requirements and build(More)
Knowledge workers rely on collaboration with a large number of knowledge. Even highly experienced knowledge workers find it difficult to keep up to date with resources available to help them complete a particular goal. This paper proposed a Context-Aware Resource Recommendation System (CARRS) to help tackle this problem. When a knowledge worker is working(More)
Business process modeling has been adopted widely. Due to the complexity, it is very hard to validate the rationality of process models. The existing validation methods can only detect structural conflicts in process models. It is also very important to validate those objects related to the processes. This paper presents a rationality validation method(More)
Shared Workspaces are getting more and more popular in helping people collaborate. However, it's difficult for user to search information across different Shared Workspaces since they are currently islands that are not interlinked. Based on semantic web technologies, SIOC provide ontology and tools to interlink online communities. By using SIOC to develop(More)