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The effect of alpha 2-adrenoceptor antagonist yohimbine (Yoh) on locus coeruleus (LC)-induced spinal antinociception was investigated in 18 anesthetized Wistar rats. Stimulation of LC markedly inhibited both nociceptive reflex of the posterior biceps semitendinosus (PBST) muscle and C responses of 16 wide-dynamic range (WDR) neurons of the dorsal horn.(More)
Using an antibody microprobe technique, we have detected substance P release from the region of the substantia gelatinosa of the cat during the first, but not the second, 30 min of topical application of capsaicin (1-3%) to the tibial nerve. Immunohistochemical analysis also showed that substance P-like immunoreactivity was markedly reduced in the(More)
An action of ohmefentanyl (OMF), a novel preferring mu opioid receptor agonist, on nociceptive response of the dorsal horn neurone, has been studied in the spinal cat. OMF (0.5-2 micrograms/kg, i.v.) produced a potent naloxone-reversible inhibition of firing of dorsal horn neurones in response to noxious heating of glabrous hindpaw or to impulses in C(More)
In 37 neurons of spinal lamina X, nociceptive responses were evoked by stimulation of the posterior articular nerve (PA) innervating the joint of hindlimb in anesthetized cats. Profound inhibition of nociceptive responses in 73.3% of neurons was induced by ohmefentanyl (1-2 micrograms.kg-1, iv), which was completely reversed by naloxone (80-330(More)
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