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Drug combination that consists of distinctive agents is an attractive strategy to combat complex diseases and has been widely used clinically with improved therapeutic effects. However, the identification of efficacious drug combinations remains a non-trivial and challenging task due to the huge number of possible combinations among the candidate drugs. As(More)
Objective. Berberine has been used to treat nonalcoholic steatohepatitis (NASH), which has been addressed in many studies. In this study, we investigated the molecular pharmacology mechanisms of berberine using metabolomic techniques. Methods. Sprague-Dawley rats were randomly divided into three groups (10 rats in each group): (i) normal control group; (ii)(More)
  • Ke-Jia Xu, Jiangning Song, Xing-Ming Zhao
  • 2010
Drug combination is becoming a popular strategy for combating complex traits, where combination of drugs improves therapy significantly over single agents. However, it is a challenging task to identify the optimal and effective combinations of drugs due to explosion of huge number of possible combinations among drugs. Therefore, it is necessary to(More)
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