Learn More
Most fruits in our daily diet are the products of domestication and breeding. Here we report a map of genome variation for a major fruit that encompasses ~3.6 million variants, generated by deep resequencing of 115 cucumber lines sampled from 3,342 accessions worldwide. Comparative analysis suggests that fruit crops underwent narrower bottlenecks during(More)
In this paper, application of sparse representation (factorization) of signals over an overcomplete basis (dictionary) for signal classification is discussed. Searching for the sparse representation of a signal over an overcomplete dictionary is achieved by optimizing an objective function that includes two terms: one that measures the signal reconstruction(More)
BACKGROUND Schizophrenia is a complex major psychiatric disorder affecting ∼1% of the world population. Recently, in a genome-wide association study and a follow-up in Caucasians, Stefansson et al. examined 7662 schizophrenic cases and 29053 normal control subjects and reported seven common single nucleotide polymorphisms (SNPs) that were significantly(More)
A recent study reported that OLIG2 had a significant association with schizophrenia in the UK population. We genotyped three variants scattered among the genomic region of OLIG2, namely rs1005573, rs762178 and rs1059004 in a sample consisting of 329 schizophrenia patients and 288 controls. The results provide further evidence that the SNP rs762178 in OLIG2(More)
—In this paper, we present an interconnection structure, called the balanced hypercube, which is a variation of the standard hypercube with desirable properties of strong connectivity, regularity, and symmetry. The proposed structure is a special type of load balanced graph designed to tolerate processor failure. In balanced hypercubes, each processor has a(More)
Multidrug resistance-associated protein (MRP-1/ABCC1) transports a wide range of therapeutic agents and may play a critical role in the development of multidrug resistance (MDR) in tumor cells. However, the regulation of MRP-1 remains controversial. To explore whether miRNAs are involved in the regulation of MRP-1 expression and modulate the sensitivity of(More)
CONTEXT Chemerin has been implicated to be correlated with inflammation. OBJECTIVE This study aims to determine the association of chemerin levels in serum and synovial fluid (SF) with the disease severity of patients with knee Osteoarthritis (OA). METHODS 124 patients with knee OA and 76 healthy controls were enrolled in this study. RESULTS Chemerin(More)
It is known that room-temperature ionic liquids (RTILs) have wide applicability in many scientific and technological fields. In this work, a series of three new dicationic room-temperature ionic liquids functionalized with poly(ethylene glycol) (PEG) linkages were synthesized and characterized via a linear solvation model. The application of these ILs as(More)
AIMS/HYPOTHESIS Glucokinase (GCK) plays a role in glucose metabolism and glucose-stimulated insulin secretion. Rare mutations in GCK cause MODY. We investigated whether common variation (minor allele frequency ≥0.01) in GCK is associated with metabolic traits and type 2 diabetes. METHODS Four exonic single-nucleotide polymorphisms (SNPs) and three SNPs(More)
The groundbreaking discovery of induced pluripotent stem cells (iPS cells) provides a new source for cell therapy. However, whether the iPS derived functional lineages from different cell origins have different immunogenicity remains unknown. It had been known that the cells isolated from extra-embryonic tissues, such as umbilical cord mesenchymal cells(More)