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Cochannel (two-talker) speech separation is predominantly addressed using pretrained speaker dependent models. In this paper, we propose an unsupervised approach to separating cochannel speech. Our approach follows the two main stages of computational auditory scene analysis: segmentation and grouping. For voiced speech segregation, the proposed system(More)
While a lot of effort has been made in computational auditory scene analysis to segregate voiced speech from monaural mixtures, unvoiced speech segregation has not received much attention. Unvoiced speech is highly susceptible to interference due to its relatively weak energy and lack of harmonic structure, and hence makes its segregation extremely(More)
Pasireotide (SOM230) is a multireceptor-targeted somatostatin analog with high binding affinity for four of the five somatostatin receptor subtypes (sst(1,2,3) and sst(5)), and potential clinical activity in several neuroendocrine and oncologic conditions, including acromegaly, Cushing's disease, and neuroendocrine tumors (NET). This manuscript reports the(More)
Unvoiced speech poses a big challenge to current monaural speech segregation systems. It lacks harmonic structure and is highly susceptible to interference due to its relatively weak energy. This paper describes a new approach to segregate unvoiced speech from nonspeech interference. The system first estimates a voiced binary mask, and then performs(More)
Unvoiced-voiced portions of cochannel speech contain considerable amounts of both voiced and unvoiced speech and play a significant role in separation. Motivated by recent developments in separation of speech from nonspeech noise, we propose a classification-based approach for unvoiced-voiced speech separation. A new feature set consisting of pitch-based(More)
This study investigated the effects of high glucose levels on human vascular endothelial cells and the expression of apoptosis-associated signaling molecules. Cell proliferation of human umbilical vein endothelial cells (HUVECs) was analyzed by colorimetric assay and cell number counting. Apoptosis was measured by Annexin V/FITC staining and flow cytometry.(More)
Singing pitch estimation and singing voice separation are challenging due to the presence of music accompaniments that are often nonstationary and harmonic. Inspired by computational auditory scene analysis (CASA), this paper investigates a tandem algorithm that estimates the singing pitch and separates the singing voice jointly and iteratively. Rough(More)
Chronic cerebral hypoperfusion (CCH) has been commonly associated with Alzheimer's disease and other types of dementia, but therapies that can improve cerebral blood flow displayed little effect on impaired cognition. Epigenetic intervention with histone deacetylase inhibitors, such as sodium butyrate (SB), on the other hand has been shown to improve(More)
Glutathione peroxidase-1 (GPx1) is a pivotal intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects. This study aims to identify a microRNA (miRNA) that targets GPx1 to maintain redox homeostasis. Dual luciferase assays combined with mutational analysis and immunoblotting were used to validate the(More)
To study the effect of endostar on the expression of hypoxia-inducible factor 1 (HIF-1) and vascular endothelial growth factor (VEGF) and radiosensitization, the changes of A549 cells treated by endostar, radiotherapy and radiotherapy plus endostar were checked by flow cytometry (FCM), methyl thiazolyl tetrazolium (MTT), hoechst staining, and enzyme linked(More)