Ke Fan

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Experimental studies have shown that the full sequence complexity of naturally occurring proteins is not required to generate rapidly folding and functional proteins, i.e. proteins can be designed with fewer than 20 letters. This raises the question of what is the minimum number of amino acid types required to encode complex protein folds? Here, we(More)
Currently, of the 10(6) known protein sequences, only about 10(4) structures have been solved. Based on homologies and similarities, proteins are grouped into different families in which each has a structural prototype, namely, the fold, and some share the same folds. However, the total number of folds and families, and furthermore, the distribution of(More)
BACKGROUND The changing pattern of hepatitis C virus (HCV) infection could have a significant impact on future medical prevention practices and therapies. OBJECTIVES The purpose of this study was to describe the changing pattern of HCV infection in southwest China using clinical epidemiology, and to assess the association between the genotypes(More)
In recent years, Global Positioning System (GPS) has been greatly utilized in collecting real-time geographic data for a mobile unit. With the latest developments in the technologies o f Geographic Information System (GIS) and wireless communications, the location data collected by a GPS unit could be easily displayed in a real-time fashion. However, for(More)
A protein model with the pairwise interaction energies varying as the local environment changes, i.e., including some kind of collective effect between the contacts, is proposed. Lattice Monte Carlo simulations on the thermodynamical characteristics and free energy profile show a well-defined two-state behavior and cooperativity of folding for such a model.(More)
BACKGROUND Thyroid dysfunction (TD) represents an extra-hepatic manifestation of chronic hepatitis C (CHC) and it may also be a side effect of interferon-alpha (IFN-α) based treatment. However, previous studies have shown a wide variation in the incidence of TD in patients with CHC. Furthermore, the long-term outcomes and the predictive factors of TD in(More)
In this paper, we propose a robust unsupervised algorithm for automatic alignment of two manifolds in different datasets with possibly different dimensionalities. The significant contribution is that the proposed alignment algorithm is performed automatically without any assumptions on the correspondences between the two manifolds. For such purpose, we(More)
Puspose: We report a case of a 17-year-old man who developed right auditory dysfunction, one month after the onset of visual loss caused by Leber's hereditary optic neuropathy (LHON). Methods: A full examination including a blood Mitochondrial DNA examination, auditory assessment and cranial magnetic resonance imaging were performed during the acute stage(More)
With the urban development and enlargement, various regions such as residential zones and administrative districts now appear as parts of cities. People exhibit different mobility patterns in each region, which is closely relevant to region-wide functions. In this article, we propose a scheme to discover region-wide functions using large-scale Shanghai(More)