Ke Fan

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Experimental studies have shown that the full sequence complexity of naturally occurring proteins is not required to generate rapidly folding and functional proteins, i.e. proteins can be designed with fewer than 20 letters. This raises the question of what is the minimum number of amino acid types required to encode complex protein folds? Here, we(More)
Currently, of the 10(6) known protein sequences, only about 10(4) structures have been solved. Based on homologies and similarities, proteins are grouped into different families in which each has a structural prototype, namely, the fold, and some share the same folds. However, the total number of folds and families, and furthermore, the distribution of(More)
In this paper, we propose a robust unsupervised algorithm for automatic alignment of two manifolds in different datasets with possibly different dimensionalities. The significant contribution is that the proposed alignment algorithm is performed automatically without any assumptions on the correspondences between the two manifolds. For such purpose, we(More)
With the urban development and enlargement, various regions such as residential zones and administrative districts now appear as parts of cities. People exhibit different mobility patterns in each region, which is closely relevant to region-wide functions. In this article, we propose a scheme to discover region-wide functions using large-scale Shanghai(More)
Highly active and low-cost electrocatalysts for water oxidation are required due to the demands on sustainable solar fuels; however, developing highly efficient catalysts to meet industrial requirements remains a challenge. Herein, we report a monolayer of nickel-vanadium-layered double hydroxide that shows a current density of 27 mA cm(-2) (57 mA cm(-2)(More)