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Personalized web search (PWS) has demonstrated its effectiveness in improving the quality of various search services on the Internet. However, evidences show that users' reluctance to disclose their private information during search has become a major barrier for the wide proliferation of PWS. We study privacy protection in PWS applications that model user(More)
Alternative products of the proteolipid protein gene (PLP), proteolipid protein (PLP) and DM20, are major components of compact myelin in the central nervous system, but quantitatively minor constituents of Schwann cells. A family with a null allele of PLP has a less severe CNS phenotype than those with other types of PLP mutations. Moreover, individuals(More)
OBJECTIVE This study used resting-state functional MRI (fMRI) to evaluate regional and network alterations in patients with Parkinson's disease (PD) with and without depression. METHOD We recruited 29 patients with PD with depression (PD-Dep), 30 patients with PD without depression (PD-NDep), and 30 normal controls. All participants underwent(More)
Oxidative stress is involved in the pathogenesis of multiple system atrophy (MSA). Uric acid has an antioxidative effect. Our aim is to clarify the correlations between serum uric acid and MSA in Chinese population. A total of 234 patients with probable MSA and 240 age- and gender- matched healthy controls were included in the study. The serum uric acid(More)
With the explosive growth of microblogging services, short-text messages (also known as tweets) are being created and shared at an unprecedented rate. Tweets in its raw form can be incredibly informative, but also overwhelming. For both end-users and data analysts it is a nightmare to plow through millions of tweets which contain enormous noises and(More)
BACKGROUND Many voxel-based morphometry studies in Alzheimer's disease (AD) and mild cognitive impairment (MCI) yielded not entirely consistent results. We conducted meta-analyses of gray matter anomalies to identify robust neuroanatomical changes between them. METHODS A systematic review of voxel-based morphometry studies of patients with AD and MCI(More)
Cancer stem cells (CSCs) have been identified as rare cell populations in many cancers, including leukemia and solid tumors. Accumulating evidence has suggested that CSCs are capable of self-renewal and differentiation into various types of cancer cells. Aberrant regulation of gene expression and some signaling pathways has been observed in CSCs compared to(More)
The assembly of 30S ribosomes requires the precise addition of 20 proteins to the 16S ribosomal RNA. How early binding proteins change the ribosomal RNA structure so that later proteins may join the complex is poorly understood. Here we use single-molecule fluorescence resonance energy transfer (FRET) to observe real-time encounters between Escherichia coli(More)
Although cardinal motor symptoms in Parkinson's disease (PD) are attributed to dysfunction of corticostriatal loops, early clinical nonmotor features are more likely to be associated with other pathologic mechanisms. We enrolled 52 early-stage drug-naive PD patients and 52 age- and sex-matched healthy controls and used resting-state functional connectivity(More)
The emerging location-based social network (LBSN) services not only allow people to maintain cyber links with their friends, but also enable them to share the events happening on them at different locations. The geo-social correlations among event participants make it possible to quantify mutual user influence for various events. Such a quantification of(More)